?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Genetic+Association+Between+Insulin+Resistance+And+Total+Cholesterol+In+Type+2+Diabetes+Mellitus+-+A+Preliminary+Observation&rft.creator=Lukshmy+Menik%2C+Hettihewa&rft.creator=Sudheera+Sammanthi%2C+Jayasinghe&rft.creator=Thilak+Priyantha%2C+Weerarathna&rft.creator=Shalika%2C+Palangasinghe&rft.creator=+Kotapola%2C+Imendra&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=We+investigated+the+degree+of+genetic+association+between+insulin+resistance+(IR)+with+type+2+diabetes+mellitus+(DM)+and+abnormalities+in+lipid+metabolism+in+42+patients.+IR+was+assessed+by+fasting+insulin+test+(FI)%2C+McAuley+(McA)%2C+HOMA+and+QUICKI+methods.+IR+was+detected+in+34+(81%25)+patients+by+FI%2C+McA+and+in+39+(93%25)+patients+by+HOMA+and+QUICKI.+26+(62%25)+patients+had+family+history+of+DM+and+23+(89%25)+of+them+displayed+IR+by+FI+%26+McA.+24+of+them+(92%25)+displayed+IR+by+HOMA+and+QUICKI.+Our+results+suggest+that+association+between+the+family+history+of+DM+and+IR+were+statistically+significant+by+chi-square+test+(P%3C0.05).+Further%2C+29+(69%25)+patients+had+elevated+total+cholesterol+levels.+Association+between+elevated+total+cholesterol+and+IR+as+assessed+by+FI+test+was+also+statistically+significant+(x2%3D4.6%3B+p%3C0.05).+Results+of+our+study+indicate+the+statistically+significant+genetic+association+of+IR+with+abnormal+cholesterol+metabolism+and+family+history+of+DM&rft.publisher=Dr.+B.S.+Kakkilaya&rft.contributor=Kakkilaya+Bevinje%2C+Dr.+Srinivas&rft.date=2005-05&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F4474%2F1%2F2005-1-4.pdf&rft.identifier=++Lukshmy+Menik%2C+Hettihewa+and+Sudheera+Sammanthi%2C+Jayasinghe+and+Thilak+Priyantha%2C+Weerarathna+and+Shalika%2C+Palangasinghe+and++Kotapola%2C+Imendra++(2005)+Genetic+Association+Between+Insulin+Resistance+And+Total+Cholesterol+In+Type+2+Diabetes+Mellitus+-+A+Preliminary+Observation.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F4474%2F