creators_name: Lukshmy, Hettihewa
creators_name: Sudheera, Jayasinghe
creators_name: Thilak, Weerarathna
creators_name: Shalika, Palangasinghe
creators_name:  Kotapola, Imendra
creators_id: Menik HL
creators_id: Sammanthi JS
creators_id: Priyantha WT
creators_id: Shalika P
creators_id: Kotapola I
editors_name: Kakkilaya, Srinivas
editors_id: Dr. B.S. Kakkilaya
type: journale
datestamp: 2005-07-15
lastmod: 2011-03-11 08:56:08
metadata_visibility: show
title: Genetic Association Between Insulin Resistance And Total Cholesterol In Type 2 Diabetes Mellitus - A Preliminary Observation
ispublished: pub
subjects: OJHAS
full_text_status: public
keywords: Type 2 diabetes, Insulin resistance, McAuley index, Dyslipidaemia
abstract: We investigated the degree of genetic association between insulin resistance (IR) with type 2 diabetes mellitus (DM) and abnormalities in lipid metabolism in 42 patients. IR was assessed by fasting insulin test (FI), McAuley (McA), HOMA and QUICKI methods. IR was detected in 34 (81%) patients by FI, McA and in 39 (93%) patients by HOMA and QUICKI. 26 (62%) patients had family history of DM and 23 (89%) of them displayed IR by FI & McA. 24 of them (92%) displayed IR by HOMA and QUICKI. Our results suggest that association between the family history of DM and IR were statistically significant by chi-square test (P<0.05). Further, 29 (69%) patients had elevated total cholesterol levels. Association between elevated total cholesterol and IR as assessed by FI test was also statistically significant (x2=4.6; p<0.05). Results of our study indicate the statistically significant genetic association of IR with abnormal cholesterol metabolism and family history of DM
date: 2005-05
date_type: published
publication: Online Journal Of Health And Allied Sciences
volume: 4
number: 1
publisher: Dr. B.S. Kakkilaya
refereed: TRUE
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citation:   Lukshmy Menik, Hettihewa and Sudheera Sammanthi, Jayasinghe and Thilak Priyantha, Weerarathna and Shalika, Palangasinghe and  Kotapola, Imendra  (2005) Genetic Association Between Insulin Resistance And Total Cholesterol In Type 2 Diabetes Mellitus - A Preliminary Observation.  [Journal (On-line/Unpaginated)]     
document_url: http://cogprints.org/4474/1/2005-1-4.pdf