--- abstract: 'We investigated the degree of genetic association between insulin resistance (IR) with type 2 diabetes mellitus (DM) and abnormalities in lipid metabolism in 42 patients. IR was assessed by fasting insulin test (FI), McAuley (McA), HOMA and QUICKI methods. IR was detected in 34 (81%) patients by FI, McA and in 39 (93%) patients by HOMA and QUICKI. 26 (62%) patients had family history of DM and 23 (89%) of them displayed IR by FI & McA. 24 of them (92%) displayed IR by HOMA and QUICKI. Our results suggest that association between the family history of DM and IR were statistically significant by chi-square test (P<0.05). Further, 29 (69%) patients had elevated total cholesterol levels. Association between elevated total cholesterol and IR as assessed by FI test was also statistically significant (x2=4.6; p<0.05). Results of our study indicate the statistically significant genetic association of IR with abnormal cholesterol metabolism and family history of DM' altloc: - http://www.ojhas.org/issue13/2005-1-4.htm chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - Menik HL - Sammanthi JS - Priyantha WT - Shalika P - Kotapola I creators_name: - family: Lukshmy given: Hettihewa honourific: '' lineage: Menik - family: Sudheera given: Jayasinghe honourific: '' lineage: Sammanthi - family: Thilak given: Weerarathna honourific: '' lineage: Priyantha - family: Shalika given: Palangasinghe honourific: '' lineage: '' - family: ' Kotapola' given: Imendra honourific: '' lineage: '' date: 2005-05 date_type: published datestamp: 2005-07-15 department: ~ dir: disk0/00/00/44/74 edit_lock_since: ~ edit_lock_until: ~ edit_lock_user: ~ editors_id: - Dr. B.S. Kakkilaya editors_name: - family: Kakkilaya given: Srinivas honourific: Dr. lineage: Bevinje eprint_status: archive eprintid: 4474 fileinfo: /style/images/fileicons/application_pdf.png;/4474/1/2005%2D1%2D4.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'Type 2 diabetes, Insulin resistance, McAuley index, Dyslipidaemia' lastmod: 2011-03-11 08:56:08 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 1 pagerange: ~ pubdom: TRUE publication: Online Journal Of Health And Allied Sciences publisher: Dr. B.S. Kakkilaya refereed: TRUE referencetext: | 1.De Fronzo RA. Lilly Lecture- The triumvirate: beta cell, muscle, liver, collusion responsible for NIDDM. Diabetes. 1987; 37:667-687. 2.Kobberling J, Tillil H. 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