creators_name: Etienne, Yves creators_name: Marjaneh, Fatemi creators_name: Jean-Jacques, Blanc editors_name: Singh, Balbir editors_name: Lokhandwala, Yash editors_name: Francis, Johnson editors_name: Gupta, Anup editors_name: Ghosh, Joydeep type: journalp datestamp: 2006-01-06 lastmod: 2011-03-11 08:56:19 metadata_visibility: show title: Left Ventricular Pacing In Patients With Congestive Heart Failure ispublished: pub subjects: ipej full_text_status: public keywords: cardiac resynchronisation, left ventricular pacing, heart failure abstract: Cardiac resynchronisation therapy (CRT) using biventricular (BIV) pacing has proved its effectiveness to correct myocardial asynchrony and improve clinical status of patients with severe congestive heart failure (CHF) and widened QRS. Despite a different effect on left ventricular electrical dispersion, left univentricular (LV) pacing is able to achieve the same mechanical synchronisation as BIV pacing in experimental studies and in humans. This results in clinical benefits of LV pacing at mid-term follow-up, with significant improvement in functional class, quality of life and exercise tolerance at the same extent as those observed with BIV stimulation in non randomised studies. Furthermore these benefits are obtained at lesser costs and with conventional dual-chamber devices. However, LV pacing has to be compared to BIV pacing in randomised trials before being definitely considered as a cost-effective alternative to BIV pacing. date: 2006-01 date_type: published publication: Indian Pacing and Electrophysiology Journal volume: 6 number: 1 publisher: Indian Pacing and Electrophysiology Group pagerange: 44-48 refereed: TRUE referencetext: 1. Cazeau S, Leclercq C, Lavergne T et al. Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay. N Engl J Med 2001;344:873-80 2. Abraham WT, Fischer WG, Smith AL et al. Cardiac reynchronization in chronic heart failure. N Engl J Med 2002;346:1845-53 3. Cleland JG, Daubert JC, Erdman E. et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Eng J Med 2005;352:1539-49 4. Gregoratos G, Abrams J, Epstein AE et al. ACC/AHA/NASPE 2002 guidelines update for implantation of cardiac pacemaker and anti-arrythmia devices: summary article ; a report of the American College of Cardiology / American Heart Association Task Force on Practice Guidelines (ACC/AHA/NASPE committee to update the 1998 Pacemaker Guidelines). Circulation 2002;106:2145-61 5. Swedberg K, Cleland J, Dargee H et al. Guidelines for the diagnosis and treatment of chronic heart failure : executive summary (update 2005) : the Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J 2005;26:1115-40 6. Xiao HB, Brecker SJ, Gibson DG. Effect of abnormal activation on the time course of the left ventricular pressure pulse in dilated cardiomyopathy. Br Heart J 1992;68:403-7 7. Leclercq C, Faris O, Tunin R et al. Systolic improvement and mechanical resynchronization does not require electrical synchrony in the dilated failing heart with left bundle branch block. Circulation 2002;106:1760-63 8. Fauchier L, Marie O, Casset-Senon D et al. Interventricular and intraventricular dysynchrony in idiopathic dilated cardiomyopathy : a prognosis study with fourier phase analysis of radionuclide angioscintigraphy. J Am Coll Cardiol 2002;40:2022-30 9. Cazeau S, Ritter P, Lazarus A et al. Multisite pacing for end-stage heart failure : early experience. Pacing Clin Electrophysiol 1996;19:1748-57 10. Blanc JJ, Etienne Y, Gilard M et al. Evaluation of different ventricular pacing sites in patients with severe heart failure : results of an acute hemodynamic study. Circulation 1997;96:3273-77 11. Kass DA, Chen CH, Curry c et al. Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation 1999;99:1567-73 12. Aurricchio A, Stellbrink C, Block M et al. Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure. Circulation 1999;99:2993-3001 13. Etienne Y, Mansourati J, Gilard M et al. Evaluation of left ventricular based pacing in patients with congestive heart failure and atrial fibrillation. Am J Cardiol 1999;83:1138-40 14. Nelson GS, Berger RD, Feties BJ et al. Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle branch block. Circulation 2000;102;3053-9 15. Etienne Y, Mansourati J, Touiza A et al. Evaluation of left ventricular function and mitral regurgitation during left ventricular-based pacing in patients with heart failure. Eur J Heart Fail 2001;3:441-47 16. Vinereanu D, Bleasdale R, Turner M et al. Comparison of left ventricular-biventricular pacing on ventricular synchrony, mitral regurgitation, and global left ventricular function in patients with severe chronic heart failure. Am J Cardiol 2004;94:519-21 17. Touiza A, Etienne Y, Gilard M et al. Long-term left ventricular pacing : assessment and comparison with biventricular pacing in patients with severe congestive heart failure. J Am Coll Cardiol 2001;38:1966-70 18. Aurricchio A, Stellbrink C, Butter C, et al. Clinical efficacy of cardiac resynchronization therapy using left ventricular pacing in heart failure patients stratified by severity of ventricular conduction delay. J Am Coll Cardiol 2003;42:2109-16 19. Blanc JJ, Bertault-Valls V, Fatemi M et al. Midterm benefits of left univentricular pacing in patients with congestive heart failure. Circulation 2004;109:1741-44 20. Aurricchio A, Stellbrink C, Sack S et al. Long-term clinical effect of hemodynamically optimized cardiac resnchronization therapy in patients with heart failure and ventricular conduction delay. J Am Coll Cardiol 2002;39:2026-33 21. Breithardt OA, Stellbrink C, Kramer AP et al. Echocardiographic quantification of left ventricular asynchrony predicts an acute hemodynamic benefit of cardiac resynchronization therapy. J Am Coll Cardiol 2002;40:536-45 22. Kawaguchi M, Murabayashi T, Fetics BJ et al. Quantification of basal dyssynchrony and acute resynchronization from left or biventricular pacing by novel echo-contrast variability imaging. J Am Coll Cardiol 2002;39:2052-8 23. Bristow MR, Saxon LA, Boehmer J, et al. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med 2004;350:2140-50 citation: Etienne, Yves and Marjaneh, Fatemi and Jean-Jacques, Blanc (2006) Left Ventricular Pacing In Patients With Congestive Heart Failure. [Journal (Paginated)] document_url: http://cogprints.org/4686/1/blanc.htm document_url: http://cogprints.org/4686/2/blanc.pdf