?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Pacemaker+Prevention+Therapy+in+Drug%E2%80%93refractory+Paroxysmal+Atrial+Fibrillation%3A+Reliability+of+Diagnostics+and+Effectiveness+of+Prevention+Pacing+Therapy+in+Vitatron%E2%84%A2+Selection%C2%AE+device&rft.creator=Terranova%2C+Paolo&rft.creator=Valli%2C+Paolo&rft.creator=Terranova%2C+Peppino&rft.creator=Dell%E2%80%99Orto%2C+Simonetta&rft.creator=Greco%2C+Enrico+Maria&rft.subject=Indian+Pacing+and+Electrophysiology+Journal&rft.description=Introduction.+Atrial+fibrillation+(AF)%2C+the+most+common+and+rising+disorder+of+cardiac+rhythm%2C+is+quite+difficult+to+control+and%2For+to+treat.+Non+pharmacological+therapies+for+AF+may+involve+the+use+of+dedicated+pacing+algorithms+to+detect+and+prevent+atrial+arrhythmia+that+could+be+a+trigger+for+AF+onset.+Selection+900E%2FAF2.0+Vitatron+DDDRP+pacemaker+(1)+keeps+an+atrial+arrhythmia+diary+thus+providing+detailed+onset+reports+of+arrhythmias+of+interest%2C+(2)+provides+us+data+about+the+number+of+premature+atrial+contractions+(PACs)+and+(3)+plots+heart+rate+in+the+5+minutes+preceding+the+detection+of+an+atrial+arrhythmia.+Moreover%2C+this+device+applies+four+dedicated+pacing+therapies+to+reduce+the+incidence+of+atrial+arrhythmia+and+AF+events.%0A%0AAim+of+the+Study.+To+analyze+the+reliability+to+record+atrial+arrhythmias+and+evaluate+effectiveness+of+its+AF+preventive+pacing+therapies.%0A%0AMaterial+and+Methods.+We+enrolled+15+patients+(9+males+and+6+females%2C+mean+age+of+71%C2%B15+years%2C+NYHA+class+I%E2%80%93II)%2C+with+a+DDDRP+pacemaker+implanted+for+a+%E2%80%9Cbradycardia%E2%80%93tachycardia%E2%80%9D+syndrome%2C+with+advanced+atrioventricular+conduction+disturbances.+We+compared+the+number+and+duration+of+AF+episodes%E2%80%99+stored+in+the+device+with+a+contemporaneous+24h+Holter+monitoring.+After+that%2C+we+switched+on+the+atrial+arrhythmias+detecting+algorithms%2C+starting+from+an+atrial+rate+over+180+beats+per+minute+for+at+least+6+ventricular+cycles%2C+and+ending+with+at+least+10+ventricular+cycles+in+sinus+rhythm.+Thereafter%2C+in+order+to+evaluate+the+possible+reduction+in+PACs+number+and+in+number+and+duration+of+AF+episodes%2C+we+tailored+all+the+four+pacing+preventive+algorithms.+Patients+were+followed+for+24%C2%B18+months+(from+20+to+32+months).%0A%0AResults.+All+59+atrial+arrhythmia+episodes+occurred+in+the+first+part+of+this+trial%2C+were+correctly+recorded+by+both+systems%2C+with+a+correlation+coefficient+(r)+of+0.96.+During+the+follow%E2%80%93up%2C+we+observed+a+significant+reduction+not+only+in+PACs+number+(from+83%C2%B112%2Fday+to+2.3%C2%B10.8%2Fday)+but+also+in+AF+episodes+(from+46%C2%B17%2Fday+to+0.12%C2%B10.03%2Fday)+and+AF+burden+(from+93%25%C2%B16%25+to+0.3%25%C2%B10.06%25).+An+increase+in+atrial+pacing+percentages+(from+3%25%C2%B10.5%25+to+97%25%C2%B13%25)+was+also+contemporaneously+observed.%0A%0AConclusion.+In+this+pacemaker%2C+detection+of+atrial+arrhythmia+episodes+is+highly+reliable%2C+thus+making+available+an+appropriate+monitoring+of+heart+rhythm%2C+mainly+suitable+in+AF+asymptomatic+patients.+Moreover%2C+the+significant+reduction+of+atrial+arrhythmia+episodes+indicates+that+this+might+represent+a+suitable+therapeutic+option+for+an+effective+preventive+therapy+of+AF+in+paced+brady%E2%80%93tachy+patients.%0A&rft.publisher=Indian+Pacing+and+Electrophysiology+Group&rft.contributor=Singh%2C+Balbir&rft.contributor=Lokhandwala%2C+Yash&rft.contributor=Francis%2C+Johnson&rft.contributor=Gupta%2C+Anup&rft.contributor=Ghosh%2C+Joydeep&rft.date=2006-04&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=text%2Fhtml&rft.identifier=http%3A%2F%2Fcogprints.org%2F4799%2F1%2Fterranova.htm&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F4799%2F2%2Fterranova.pdf&rft.identifier=++Terranova%2C+Paolo+and+Valli%2C+Paolo+and+Terranova%2C+Peppino+and+Dell%E2%80%99Orto%2C+Simonetta+and+Greco%2C+Enrico+Maria++(2006)+Pacemaker+Prevention+Therapy+in+Drug%E2%80%93refractory+Paroxysmal+Atrial+Fibrillation%3A+Reliability+of+Diagnostics+and+Effectiveness+of+Prevention+Pacing+Therapy+in+Vitatron%E2%84%A2+Selection%C2%AE+device.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F4799%2F