creators_name: Patnayak, Rashmi creators_name: Prayaga, Aruna creators_name: Reddy, Rajasekhar creators_name: S.V.N., Anuradha creators_name: E, Jayasankar type: journale datestamp: 2006-09-01 lastmod: 2011-03-11 08:56:34 metadata_visibility: show title: An intriguing autopsy case of gangrene intestine ispublished: pub subjects: calcut full_text_status: public abstract: Hypothyroidism, or myxedema, is the clinical syndrome that results from decreased production of T4 and T3.Most patients have primary hypothyroidism .The etiology of adult primary hypothyroidism includes autoimmune hypothyroidism (Hashimoto’s thyroiditis), post – ablation after radio-active iodine, thyroid surgery and drugs such as Amiodarone and Lithium. Manifestations are variable and proportionate to the degree and duration of thyroid hormone deficiency as well as age of onset. The presence of goiter is common in younger patients (Hashimoto’s) but often absent in the elderly. Clinical features of hypothyroidism are insidious and often missed, particularly in the elderly. date: 2006 date_type: published publication: Calicut Medical Journal volume: 4 number: 3 publisher: Calicut Medical College Alumni Association refereed: TRUE referencetext: 1. Cecilia M. Fenoglio-Preiser, Amy E. Noffsinger, Grant N. Stemmermann, Patrick E. Lantz, Margaret B. Listrom, Franco O. Rilke.Nonneoplastic lesions of the small intestine. In: Gastrointestinal Pathology, eds.2nd edition. Philadelphia, Lippincott-Raven, 1998,341-348 Patnayak et al Calicut Medical Journal 2006;4(3):e3 Page 4 (Page number not for indexing purposes) 2. Stassi G, De Maria R: Autoimmune thyroid disease: new models of cell death in autoimmunity. Nat Rev Immunol2 (3): 195-204,2002 3. Pearce EN, Farwell AP, Braverman LE: Thyroiditis Engl J Med 348:2646,2003 4. Thompson GR, Soutar AK, Spengel FA, Jadhav A, Gavigan SJ, Myant NB 1981 Defects of receptor-mediated low density lipoprotein catabolism in homozygous familial hypercholesterolemia and hypothyroidism in vivo. Proc Natl Acad Sci USA 78:2591–2595 5. Steinberg AD.Myxedema and coronary artery disease: a comparative autopsy study. Ann Intern Med 1968; 68:338 – 344. 6. Bergus. GR, Randall. C, Van.Peursem.R, Lack of association between hypertension and hypothyroidism in a primary care setting Hum Hypertens. 1999; 13:231 – 5. 7. Bergus. GR, Randall. C, Van.Peursem.R, Lack of association between hypertension and hypothyroidism in post-menopausal women in a primary care setting AM Board – Fam – Pract.1997; 10:185-01. 8. Jrven O, Laurika J, Salenius JP, Tarkka M, Acute intestinal ischemia: a review of 214 cases .Ann Chir Gynaecol 1994; 83:22-25 9. Reinus JF, Brandt LJ, Boley SJ.Ischemic disease of the bowel. Gastroenterol Clin North Am 1990; 19:319-343 citation: Patnayak, Rashmi and Prayaga, Aruna and Reddy, Rajasekhar and S.V.N., Anuradha and E, Jayasankar (2006) An intriguing autopsy case of gangrene intestine. [Journal (On-line/Unpaginated)] document_url: http://cogprints.org/5091/1/e3.pdf