creators_name: Grimm, Oliver creators_name: Hubrich, Petra type: preprint datestamp: 2006-09-01 lastmod: 2011-03-11 08:56:35 metadata_visibility: show title: Delusional Belief induced by clomiphene treatment subjects: neuro-psych full_text_status: public keywords: estrogene, clomiphene, psychosis, delusion abstract: We report the case of a 35 year old women who developed a complex paranoid delusion during the course of clomiphene treatment für ovulation. The psychopathology was remarkable, because after a short hypomanic period the patient was without severe cognitive disturbance but struggled with a complex monothematic delusion. The delusion vanished in the course of a combination treatment with olanzapine a cognitive behavioral therapy. We could not entirely rule out the possibility of an endogenous psychiatric disease but nevertheless we encountered an unusual monothematic delusion which showed a strong temporal correlation with the intake of clomiphene. We provide some speculation about underlying neurobiological mechanisms on the basis of the dopamine theory of delusion. date: 2006-01 date_type: published refereed: FALSE referencetext: Arvin, M., Fedorkova, L., Disshon, K. A., Dluzen, D. E. and Leipheimer, R. E. "Estrogen modulates responses of striatal dopamine neurons to MPP(+): evaluations using in vitro and in vivo techniques." Brain Res, 2000, 872(1-2), pp. 160-71. Becker, J. B. "Oestrogen effects on dopaminergic function in striatum." Novartis Found Symp, 2000, 230pp. 134-45; discussion 145-54. Cashman, F. E. and Sheppard, R. "Clomiphene citrate as a possible cause of psychosis." Can Med Assoc J, 1982, 126(2), pp. 118. McDermott, J. L., Anderson, L. I. and Dluzen, D. E. "Interactive effects of tamoxifen and estrogen upon the nigrostriatal dopaminergic system." Neuroendocrinology, 1997, 66(3), pp. 181-7. Oyffe, I., Lerner, A., Isaacs, G., Harel, Y. and Sigal, M. "Clomiphene-induced psychosis." Am J Psychiatry, 1997, 154(8), pp. 1169-70. Siedentopf, F., Horstkamp, B., Stief, G. and Kentenich, H. "Clomiphene citrate as a possible cause of a psychotic reaction during infertility treatment." Hum Reprod, 1997, 12(4), pp. 706-7. Spitzer, M. "A neurocomputational approach to delusions." Compr Psychiatry, 1995, 36(2), pp. 83-105. citation: Grimm, Dr. Oliver and Hubrich, Dr. Petra (2006) Delusional Belief induced by clomiphene treatment. [Preprint] document_url: http://cogprints.org/5095/1/Delusional_Belief_induced_by_clomiphene_treatment.txt document_url: http://cogprints.org/5095/2/Delusional_Belief_induced_by_clomiphene_treatment.pdf