?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=fMRI+Investigation+of+Cortical+and+Subcortical+Networks+in+the+Learning+of+Abstract+and+Effector-Specific+Representations+of+Motor+Sequences&rft.creator=Bapi%2C+Dr.+Raju+S.&rft.creator=Miyapuram%2C+Mr.+K.+P.&rft.creator=Graydon%2C+Dr.+F.+X.&rft.creator=Doya%2C+Dr.+Kenji&rft.subject=Brain+Imaging&rft.description=A+visuomotor+sequence+can+be+learned+as+a+series+of+visuo-spatial+cues+or+as+a+sequence+of+effector+movements.+Earlier+imaging+studies+have+revealed+that+a+network+of+brain+areas+is+activated+in+the+course+of+motor+sequence+learning.+However+these+studies+do+not+address+the+question+of+the+type+of+representation+being+established+at+various+stages+of+visuomotor+sequence+learning.+In+an+earlier+behavioral+study%2C+we+demonstrated+that+acquisition+of+visuo-spatial+sequence+representation+enables+rapid+learning+in+the+early+stage+and+progressive+establishment+of+somato-motor+representation+helps+speedier+execution+by+the+late+stage.+We+conducted+functional+magnetic+resonance+imaging+(fMRI)+experiments+wherein+subjects+learned+and+practiced+the+same+sequence+alternately+in+normal+and+rotated+settings.++In+one+rotated+setting+(visual)%2C+subjects+learned+a+new+motor+sequence+in+response+to+an+identical+sequence+of+visual+cues+as+in+normal.+In+another+rotated+setting+(motor)%2C+the+display+sequence+was+altered+as+compared+to+normal%2C+but+the+same+sequence+of+effector+movements+were+used+to+perform+the+sequence.++Comparison+of+different+rotated+settings+revealed+analogous+transitions+both+in+the+cortical+and+subcortical+sites+during+visuomotor+sequence+learning+%EF%82%BE+a+transition+of+activity+from+parietal+to+parietal-premotor+and+then+to+premotor+cortex+and+a+concomitant+shift+was+observed+from+anterior+putamen+to+a+combined+activity+in+both+anterior+and+posterior+putamen+and+finally+to+posterior+putamen.+These+results+suggest+a+putative+role+for+engagement+of+different+cortical+and+subcortical+networks+at+various+stages+of+learning+in+supporting+distinct+sequence+representations.&rft.date=2006-08&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5114%2F1%2FBapi_NeuroImage_preprint.pdf&rft.identifier=++Bapi%2C+Dr.+Raju+S.+and+Miyapuram%2C+Mr.+K.+P.+and+Graydon%2C+Dr.+F.+X.+and+Doya%2C+Dr.+Kenji++(2006)+fMRI+Investigation+of+Cortical+and+Subcortical+Networks+in+the+Learning+of+Abstract+and+Effector-Specific+Representations+of+Motor+Sequences.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5114%2F