---
abstract: 'Syphilis has acquired new potential for morbidity and mortality through association with increased risk for HIV infection. Case-control survey was conducted using Rapid Plasma Reagin test and confirmatory Immunochromatographic test among HIV-positive (cases) and HIV-negative (control) Nigerians. A total of 35(14.0%) of 250 HIV-positive and 5(2.0%) of 250 HIV-negative individuals studied were seropositive for syphilis, the difference was statistically significant (P<0.05). The prevalence was higher among females than males of HIV-positive (15.0% versus 12.7%) and of the HIV-negative (2.1% versus 1.9%) individuals. Syphilis seroprevalence was highest among HIV-positive individuals aged 21-30 years (20.5%) and 41-50 years old HIV-negative individuals (4.5%). Sex education, promotion of safer sexual behaviour, prompt diagnosis of STDs and provision of effective, accessible treatment are recommended'
altloc:
- http://www.ojhas.org/issue18/2006-2-5.htm
chapter: ~
commentary: ~
commref: ~
confdates: ~
conference: ~
confloc: ~
contact_email: ~
creators_id:
- Uneke CJ
- Ogbu O
- Alo M
- Ariom T
creators_name:
- family: Uneke
given: Chigozie
honourific: ''
lineage: Jesse
- family: Ogbu
given: Ogbonnaya
honourific: ''
lineage: ''
- family: Alo
given: Moses
honourific: ''
lineage: ''
- family: Ariom
given: Thaddeus
honourific: ''
lineage: ''
date: 2006-09
date_type: published
datestamp: 2006-09-25
department: ~
dir: disk0/00/00/51/69
edit_lock_since: ~
edit_lock_until: ~
edit_lock_user: ~
editors_id:
- Kakkilaya BS
- Baliga BS
editors_name:
- family: Kakkilaya
given: Srinivas
honourific: Dr.
lineage: Bevinje
- family: Baliga
given: Shatharam
honourific: Dr.
lineage: B
eprint_status: archive
eprintid: 5169
fileinfo: /style/images/fileicons/application_pdf.png;/5169/1/2006%2D2%2D5.pdf
full_text_status: public
importid: ~
institution: ~
isbn: ~
ispublished: pub
issn: ~
item_issues_comment: []
item_issues_count: 0
item_issues_description: []
item_issues_id: []
item_issues_reported_by: []
item_issues_resolved_by: []
item_issues_status: []
item_issues_timestamp: []
item_issues_type: []
keywords: 'Syphilis, Treponema pallidum, HIV, Seroprevalence'
lastmod: 2011-03-11 08:56:36
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: 2
pagerange: ~
pubdom: TRUE
publication: Online Journal Of Health And Allied Sciences
publisher: Dr. B.S. Kakkilaya
refereed: TRUE
referencetext: |-
1. World Health Organization (WHO). Global prevalence and incidence of selected curable sexually transmitted infections. Overview and estimates. Geneva:World Health Organization; 2001.
2. Cohen MS. Sexually transmitted diseases enhance HIV transmission: no longer a hypothesis. Lancet. 1998;351:5-7.
3. Zeltser R, Kurban AK. Syphilis. Clin Dermatol. 2004;22:461-468.
4. Tramont EC. Syphilis in adults: From Christopher Columbus to Sir Alexander Fleming to AIDS. Clin Infect Dis. 1995;21:1361-1369.
5. Johns DR, Tierney M, Felsenstein D. Alteration in the natural history of neurosyphilis by concurrent infection with the human immunodeficiency virus. N Engl J Med. 1987;316:1569-1572.
6. O'Mahony C, Rodgers CA, Mendelsohn SS, et al. Rapidly progressive syphilis in early HIV infection. Int J Sex Trans Dis AIDS. 1997;8:275-277.
7. Bolan G. Syphilis and HIV. HIV InSite Knowledge Base Chapter. 1998. Available at: http://hivinsite.ucsf.edu/InSite?page=kb-05&doc=kb-05-01-04. Accessed February 5, 2006.
8. Wasserheit JN. Epidemiological synergy: Interrelationships between human immunodeficiency virus infection and other sexually transmitted diseases. Sex Transm Dis. 1992;19:61-77.
9. Schmid G. Economic and programmatic aspects of congenital syphilis prevention. Bull WHO. 2004;82:402-409.
10. World Health Organization (WHO). AIDS epidemic update. Geneva: UNAIDS/WHO; 2004.
11. Ministry of Health South Africa (MOHSA). National HIV and Syphilis Sero-Prevalence Survey of Women attending Public Antenatal Clinics in South Africa. Johannesburg: MOHSA; 2001.
12. Federal Ministry of Health Nigeria (FMOHN). Technical report on 2001 national HIV/syphilis sentinel survey among pregnant women attending antenatal clinics in Nigeria. Abuja: FMOHN; 2004.
13. Tsegaye A, Rinke de Wit TF, Mekonnen Y, et al. Decline in the prevalence of HIV- infection and syphilis among women attending antenatal care clinic in Addis Ababa, Ethiopia: Results from sentinel surveillance, 1995-2001. J Acquir Immune Syndr. 2002;30:359-362
14. United Nations System in Nigeria (UNSN). Nigerian Common Country Assessment.Geneva: World Health Organization; 2001.
15. Cheesbrough M. District Laboratory Practice in Tropical Countries. Part 2. Cambridge University Press; 2000.
16. U.S. Preventive Services Task Force (USPSTF). Screening for Syphilis: Brief Update. Agency for Healthcare Research and Quality, Rockville, MD. 2004. Available at: http://www.ahrq.gov/clinic/3rduspstf/syphilis/syphilup.htm. Accessed February 5, 2006.
17. Hart G. Syphilis tests in diagnostic and therapeutic decision making. Ann Intern Med. 1986;104:368-376.
18. Dorigo-Zetsma JW, Belewu D, Meless H, et al. Performance of routine syphilis serology in the Ethiopian cohort on HIV/AIDS. Sex Transm Infect. 2004;80:96-99.
19. Golden MR, Marra CM, Holmes KK. Update on syphilis: Resurgence of an old problem. JAMA. 2003;290:1510-1514.
20. Rodriguez I, Rodriguez ME, Fernandez C, et al. Serological diagnosis of syphilis in Cuban HIV/AIDS patients. Rev Cubana Med Trop. 2004;56:67-69.
21. Bowen DL, Lane HC, Fauci AS. Immunopathogenesis of the acquired immunodeficiency syndrome. Ann Intern Med. 1985;103:704-709.
22. Uneke CJ, Ogbu O, Inyama PU, et al. Prevalence of hepatitis-B surface antigen among blood donors and human immunodeficiency virus-infected patients in Jos, Nigeria Mem Inst Oswaldo Cruz. 2005;100:13-16.
23. Nusbaum MR, Wallace RR, Slatt LM, et al. Sexually transmitted infections and increased risk of co-infection with human immunodeficiency virus. J Am Osteopathol Assoc. 2004;104: 527-35.
24. Rompalo AM, Cannon RO, Quinn TC, et al. Association of biologic false-positive reactions for syphilis with human immunodeficiency virus infection. J Infect Dis. 1992;165:1124-1126.
25. Young H. Syphilis: new diagnostic directions [editorial review]. International J Sex Transm Dis AIDS. 1992;3:391-413.
26. Augenbraun MH, DeHovitz JA, Feldman J. Biologic false-positive syphilis test results for women infected with human immunodeficiency virus. Clin Infect Dis. 1994;19:1040– 1044.
27. Erbelding EJ, Vlahov D, Nelson KE, et al. Syphilis serology in human immunodeficiency virus infection: evidence for false-negative fluorescent treponemal testing. J Infect Dis.1997;176:1397–1400.
28. Centers for Disease Control and Prevention (CDC). National Center for HIV, and TB Prevention, Prevention DoS. Sexually transmitted disease surveillance 2001 supplement: Syphilis surveillance report. Atlanta, GA: Department of Health and Human Services; 2003.
29. Hwang LY, Ross MW, Zack C, et al. Prevalence of STIs and association risk factors among population of drug abuse. J Clin Infect. 2000;319:920-926.
30. Todd J, Muguti K, Grosskurlt H, et al. Risk factors for active syphilis and TPHA seroconversion in a rural Africa population. J Sex Transm Infect. 2001;7:37-45.
31. Gourevitch MN, Hartel D, Schenbaum EE, et al. A prospective study of syphilis and HIV infection among injection drug users receiving methadone in the Bronx. Am J Pub Health. 1996;86:1112- 1115.
32. World Health Organization (WHO). The World Health Report 2002: reducing risks, promoting healthy life. Geneva: World Health Organization; 2002.
33. International Development Research Centre (IDRC). Population and Health in Developing Countries, Vol 1. Ottawa: Population health and survival at INDEPTH sites; 2002.
relation_type: []
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reportno: ~
rev_number: 12
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status_changed: 2007-09-12 17:07:29
subjects:
- OJHAS
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: 'Syphilis serology in HIV-positive and HIV-negative Nigerians: The public health significance'
type: journale
userid: 4338
volume: 5