?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=A+theory+of+general+impairment+of+gene-expression+manifesting+as+autism&rft.creator=Clarke%2C+R.P.&rft.subject=Developmental+Psychology&rft.subject=Behavioral+Biology&rft.subject=Clinical+Psychology&rft.description=This+is+the+first+part+of+a+combined+theory+of+autism+and+general+intelligence+(IQ).++It+is+argued+that+general+impairment+of+gene-expression%2C+produced+by+a+diversity+of+environmental+and+genetic+causes%2C+is+in+moderation+advantageous+in+suppressing+genetic+idiosyncracies.++But+in+excess+it+will+produce+a+condition+involving+abnormalities+of+appearance+and+behaviour%2C+with+a+particular+relationship+to+high+parental+social+class+and+IQ+and+with+particular+sex+distributions.++Characteristics+and+findings+relating+to+schizophrenia%2C+manic-depressive+illness%2C+or+neuroses+indicate+that+they+cannot+reasonably+be+considered+manifestations+of+excessive+general+impairment+of+gene-expression.++By+contrast%2C+characteristics+and+findings+relating+to+autism+accord+very+well+with+this+conception.++The+suggestion+is+that+autism+involves+primary+abnormalities+in+diverse+parts+of+the+brain+and+in+diverse+psychological+functions.++Random+binding+to+DNA+may+be+a+substantial+mechanism+of+general+impairment+of+gene-expression.++%5Bi.e.%2C+would+definitely+cause+impairment%2C+and+hence+cause+autism%2C+but+only+may+be+substantially+involved+(see+para.+15)%5D.&rft.publisher=Pergamon&rft.contributor=Eysenck%2C+Prof.+H.J.&rft.contributor=Eysenck%2C+Dr.+S.G.+B.&rft.date=1993-03&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5207%2F1%2FAutTheo.pdf&rft.identifier=++Clarke%2C+R.P.++(1993)+A+theory+of+general+impairment+of+gene-expression+manifesting+as+autism.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5207%2F