TY  - GEN
ID  - cogprints5300
UR  - http://cogprints.org/5300/
A1  - Bracha, HS
A1  - Gil, P
A1  - Lange, B
A1  - Gilder, J
A1  - Torrey, EF
A1  - Gottesman, II
A1  - McCray, DS
Y1  - 1995///
N2  - Summary: We tested the hypothesis that gestational injuries in some patients with schozophrenia would leave their mark as a subtle reduction in head circumference (subclinical microcrania).  

Conclusions: The head circumferences of all subjects were in the normal range.  Decreased head circumference in affected MZ co-twins (relative to unaffected MZ co-twin) characteriazes discordant MZ pairs with larger finger-ridge-count differences (i.e., second-trimester fetal-size differences).  This study using ideal genetic controls suggests that, while present only in some patients with schizophrenia, the decrease in head circumference is most likely a consequence of in-utero nonshared environmental deleterious events manifesting as groth retardation or as fetal edema and occurring around the fifth prenatal month.  
KW  - Schizophrenia
KW  -  Etiology
KW  -  Embryology
KW  -  Neurodevelopment
KW  -  Dysmorphology
KW  -  Dermatoglyphics
KW  -  Twins
KW  -  Monozygotic
KW  -  Nonshared environment
TI  - Subclinical microcrania, subclinical macrocrarnia, and fifth-month fetal markers (of growth retardation or edema) in schizophrenia: a co-twin control study of discordant monozygotic twins.
SP  - 44
AV  - public
EP  - 52
ER  -

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