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%A HS Bracha
%A P Gil
%A B Lange
%A J Gilder
%A EF Torrey
%A II Gottesman
%A DS McCray
%J Neropsychiatry, Neuropsychology, and Behavioral Neurology
%T Subclinical microcrania, subclinical macrocrarnia, and fifth-month fetal markers (of growth retardation or edema) in schizophrenia: a co-twin control study of discordant monozygotic twins.
%X Summary: We tested the hypothesis that gestational injuries in some patients with schozophrenia would leave their mark as a subtle reduction in head circumference (subclinical microcrania).
Conclusions: The head circumferences of all subjects were in the normal range. Decreased head circumference in affected MZ co-twins (relative to unaffected MZ co-twin) characteriazes discordant MZ pairs with larger finger-ridge-count differences (i.e., second-trimester fetal-size differences). This study using ideal genetic controls suggests that, while present only in some patients with schizophrenia, the decrease in head circumference is most likely a consequence of in-utero nonshared environmental deleterious events manifesting as groth retardation or as fetal edema and occurring around the fifth prenatal month.
%N 1
%K Schizophrenia, Etiology, Embryology, Neurodevelopment, Dysmorphology, Dermatoglyphics, Twins, Monozygotic, Nonshared environment
%P 44-52
%V 8
%D 1995
%L cogprints5300