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abstract: |-
Summary: We tested the hypothesis that gestational injuries in some patients with schozophrenia would leave their mark as a subtle reduction in head circumference (subclinical microcrania).
Conclusions: The head circumferences of all subjects were in the normal range. Decreased head circumference in affected MZ co-twins (relative to unaffected MZ co-twin) characteriazes discordant MZ pairs with larger finger-ridge-count differences (i.e., second-trimester fetal-size differences). This study using ideal genetic controls suggests that, while present only in some patients with schizophrenia, the decrease in head circumference is most likely a consequence of in-utero nonshared environmental deleterious events manifesting as groth retardation or as fetal edema and occurring around the fifth prenatal month.
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creators_name:
- family: Bracha
given: HS
honourific: ''
lineage: ''
- family: Gil
given: P
honourific: ''
lineage: ''
- family: Lange
given: B
honourific: ''
lineage: ''
- family: Gilder
given: J
honourific: ''
lineage: ''
- family: Torrey
given: EF
honourific: ''
lineage: ''
- family: Gottesman
given: II
honourific: ''
lineage: ''
- family: McCray
given: DS
honourific: ''
lineage: ''
date: 1995
date_type: published
datestamp: 2006-12-22
department: ~
dir: disk0/00/00/53/00
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eprint_status: archive
eprintid: 5300
fileinfo: /style/images/fileicons/application_pdf.png;/5300/1/Bracha_et_al.%2C_Subclinical_microcrania%2C_subclinical_macrocrarnia%2C_and_fifth%2Dmonth_fetal_markers_(of_growth_retardation_or_edema)_in_schizophrenia_a_co%2Dtwin_control_study_of_discordant_monozygotic_twins..PDF
full_text_status: public
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item_issues_comment: []
item_issues_count: 0
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keywords: 'Schizophrenia, Etiology, Embryology, Neurodevelopment, Dysmorphology, Dermatoglyphics, Twins, Monozygotic, Nonshared environment'
lastmod: 2011-03-11 08:56:44
latitude: ~
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metadata_visibility: show
note: ~
number: 1
pagerange: 44-52
pubdom: FALSE
publication: 'Neropsychiatry, Neuropsychology, and Behavioral Neurology'
publisher: ~
refereed: FALSE
referencetext: ~
relation_type: []
relation_uri: []
reportno: ~
rev_number: 10
series: ~
source: ~
status_changed: 2007-09-12 17:08:53
subjects:
- neuro-psych
- neuro-neu
succeeds: ~
suggestions: ~
sword_depositor: ~
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thesistype: ~
title: 'Subclinical microcrania, subclinical macrocrarnia, and fifth-month fetal markers (of growth retardation or edema) in schizophrenia: a co-twin control study of discordant monozygotic twins.'
type: journalp
userid: 6567
volume: 8