---
abstract: "Phencyclidine (PCP; angel dust) is a drug of abuse known to produce a behavioral state in humans resembling schizophrenia/psychosis. PCP is a noncompetitive NMDA receptor antagonist and produces a variety of behaviors in rats including circling. The behavioral effects of other noncompetitive NMDA receptor antagonists such as (+)-MK-801 are still being elucidated. Here, adult female rats were dosed with PCP (10 mg/kg, IP), or (+)-MK-801 (0.1 mg/kg, IP) and circling preference was recorded for 2 h before sacrifice to determine monoamine levels by HPLC/EC. Animals injected with PCP or (+)-MK-801 showed a preference to turn to the left (65% and 72%, respectively). PCP and (+)-MK-801 also produced a significant increase of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in whole striatum on both sides of the brain. Further dissection of the striatum into medioventral and dorsolateral regions revealed that HVA was increased bilaterally except in globus pallidus where we found significant increases in dopamine (DA), DOPAC, and HVA only on the left side after PCP and (+)-MK-801 administration. These data suggest that PCP and (+)-MK-801 produce a greater preference to turn left than right, a finding similar to that found in human psychosis. Furthermore, it is possible that this preference to turn toward the left hemispace is due to an asymmetry in dopamine function found in the globus pallidus after administration of PCP and similar drugs.\n"
altloc: []
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creators_name:
- family: Ali
given: SF
honourific: ''
lineage: ''
- family: Newport
given: GD
honourific: ''
lineage: ''
- family: Bracha
given: HS
honourific: ''
lineage: ''
date: 1994
date_type: published
datestamp: 2006-12-22
department: ~
dir: disk0/00/00/53/01
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editors_id: []
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eprint_status: archive
eprintid: 5301
fileinfo: /style/images/fileicons/application_pdf.png;/5301/1/1994_NMDA_antagonist_(PCP_Phencyclidine%2C_(%2B)%2DMK%2D801)_induced_circling_behavior.PDF
full_text_status: public
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isbn: ~
ispublished: pub
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item_issues_comment: []
item_issues_count: 0
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item_issues_reported_by: []
item_issues_resolved_by: []
item_issues_status: []
item_issues_timestamp: []
item_issues_type: []
keywords: 'glutamate, NMDA receptor, PCP, angel dust, phencyclidine, dopamine assymetry, ketamine, acute psychosis'
lastmod: 2011-03-11 08:56:44
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: 4
pagerange: 335-342
pubdom: FALSE
publication: Neurotoxicology and Teratology
publisher: ~
refereed: TRUE
referencetext: ~
relation_type: []
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reportno: ~
rev_number: 10
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source: ~
status_changed: 2007-09-12 17:08:54
subjects:
- ihealth
succeeds: ~
suggestions: ~
sword_depositor: ~
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thesistype: ~
title: 'Phencyclidine and (+)-MK-801-induced circling preference: correlation with monoamine levels in striatum of the rat brain'
type: journalp
userid: 6567
volume: 16