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abstract: '“Uner Tan Syndrome” consists of two main symptoms: quadrupedal gait and primitive cognitive abilities including language and conscious experience. To assess the central mechanisms involved in this syndrome, we performed MRI and PET scans on affected and unaffected individuals from both families. All affected individuals were also subjected to neurological examination. To assess the integrity of the peripheral and central vestibular system, Barany’s caloric test was applied to the affected individuals. Brain MRI and PET scans were performed on normal subjects (N = 7) and patients (N = 7). Right- and left-cerebral and cerebellar areas, including the vermial and callosal areas, were measured on the MRI scans using a computer cursor. Quadrupedal gait, mental retardation, dysartric speech, nystagmus, severe truncal ataxia, hyperreflexia, astasia and abasia were observed in the affected individuals from both families. Cerebellum and vermis were atrophic in the MRI and PET scans of the first family. In contrast, the brain MRI seemed to be normal in the MRI and PET scans of affected individuals from the second family. The caloric test revealed central vestibular damage in patients from the first family and peripheral vestibular damage in patients from the second family. The results suggest that “Uner Tan Syndrome”, discovered in two unrelated families, may be caused by peripheral or central vestibular damage resulting from different genetic defects. Cerebellar hypoplasia may not be a prerequisite for the emergence of this syndrome. Primitive mental abilities may be explained by damage within the vestibulo-cerebellar system, while the quadrupedal gait may be due to a genetic defect within the higher brain centers that suppress the atavistic brain networks controlling quadrupedal gait and helped in the emergence of the habitual bipedal gait during human evolution. This retarded development of human locomotion –devolution- may illuminate the brain mechanisms responsible for the transition from quadrupedality to bipedality in human evolution.'
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creators_name:
- family: TAN
given: Üner
honourific: Prof. Dr.
lineage: ''
- family: PENÇE
given: Sadrettin
honourific: Dr.
lineage: ''
- family: YILMAZ
given: Mustafa
honourific: Dr.
lineage: ''
- family: ÖZKUR
given: Ayhan
honourific: Dr.
lineage: ''
- family: KARACA
given: Sibel
honourific: Dr.
lineage: ''
- family: TAN
given: Meliha
honourific: Dr.
lineage: ''
- family: KARATAŞ
given: Mehmet
honourific: Dr.
lineage: ''
date: 2006
date_type: published
datestamp: 2007-02-19
department: ~
dir: disk0/00/00/53/87
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editors_id: []
editors_name: []
eprint_status: archive
eprintid: 5387
fileinfo: /style/images/fileicons/application_pdf.png;/5387/1/WRIST_WALKER_NO_UT_SYND.pdf
full_text_status: public
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keywords: 'Üner Tan Syndrome, quadrupedality, bipedality, MRI, PET, cerebellum, brain, devolution, reverse evolution'
lastmod: 2011-03-11 08:56:46
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referencetext: |-
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relation_type: []
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reportno: ~
rev_number: 14
series: ~
source: ~
status_changed: 2007-09-12 17:09:29
subjects:
- neuro-neu
- evol-psy
succeeds: ~
suggestions: ~
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title: '“UNER TAN SYNDROME” IN TWO TURKISH FAMILIES IN RELATION TO DEVOLUTION AND EMERGENCE OF HOMO ERECTUS: NEUROLOGICAL EXAMINATION, MRI AND PET SCANS'
type: preprint
userid: 4979
volume: ~