?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Neuroprotective+efficacy+of+nimesulide+against+hippocampal+neuronal+damage+following+transient+forebrain+ischemia&rft.creator=Candelario-Jalil%2C+Eduardo&rft.creator=Alvarez%2C+Dalia&rft.creator=Gonzalez-Falcon%2C+Armando&rft.creator=Garcia-Cabrera%2C+Michel&rft.creator=Martinez-Sanchez%2C+Gregorio&rft.creator=Merino%2C+Nelson&rft.creator=Giuliani%2C+Attilia&rft.creator=Leon%2C+Olga+S.&rft.subject=Neurochemistry&rft.description=Cyclooxygenase-2+is+involved+in+the+inflammatory+component+of+the+ischemic+cascade%2C+playing+an+important+role+in+the+delayed+progression+of+the+brain+damage.+The+present+study+evaluated+the+pharmacological+effects+of+the+selective+cyclooxygenase-2+inhibitor+nimesulide+on+delayed+neuronal+death+of+hippocampal+CA1+neurons+following+transient+global+cerebral+ischemia+in+gerbils.+Administration+of+therapeutically+relevant+doses+of+nimesulide+(3%2C+6+and+12+mg%2Fkg%3B+i.p.)+30+min+before+ischemia+and+at+6%2C+12%2C+24%2C+48+and+72+h+after+ischemia+significantly+(P%3C0.01)+reduced+hippocampal+neuronal+damage.+Treatment+with+a+single+dose+of+nimesulide+given+30+min+before+ischemia+also+resulted+in+a+significant+increase+in+the+number+of+healthy+neurons+in+the+hippocampal+CA1+sector+7+days+after+ischemia.+Of+interest+is+the+finding+that+nimesulide+rescued+CA1+pyramidal+neurons+from+ischemic+death+even+when+treatment+was+delayed+until+24+h+after+ischemia+(34%2B%2F-9%25+protection).+Neuroprotective+effect+of+nimesulide+is+still+evident+30+days+after+the+ischemic+episode%2C+providing+the+first+experimental+evidence+that+cyclooxygenase-2+inhibitors+confer+a+long-lasting+neuroprotection.+Oral+administration+of+nimesulide+was+also+able+to+significantly+reduce+brain+damage%2C+suggesting+that+protective+effects+are+independent+of+the+route+of+administration.+The+present+study+confirms+the+ability+of+cyclooxygenase-2+inhibitors+to+reduce+brain+damage+induced+by+cerebral+ischemia+and+indicates+that+nimesulide+can+provide+protection+when+administered+for+up+to+24+h+post-ischemia.&rft.publisher=Elsevier&rft.date=2002&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5643%2F1%2FEur_J_Pharmacol_2002_Candelario-Jalil_et_al.pdf&rft.identifier=++Candelario-Jalil%2C+Eduardo+and+Alvarez%2C+Dalia+and+Gonzalez-Falcon%2C+Armando+and+Garcia-Cabrera%2C+Michel+and+Martinez-Sanchez%2C+Gregorio+and+Merino%2C+Nelson+and+Giuliani%2C+Attilia+and+Leon%2C+Olga+S.++(2002)+Neuroprotective+efficacy+of+nimesulide+against+hippocampal+neuronal+damage+following+transient+forebrain+ischemia.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5643%2F