?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=The+highly+selective+cyclooxygenase-2+inhibitor+DFU+is+neuroprotective+when+given+several+hours+after+transient+cerebral+ischemia+in+gerbils&rft.creator=Candelario-Jalil%2C+Eduardo&rft.creator=Alvarez%2C+Dalia&rft.creator=Castaneda%2C+Juana+M.&rft.creator=Al-Dalain%2C+Saied+M.&rft.creator=Martinez-Sanchez%2C+Gregorio&rft.creator=Merino%2C+Nelson&rft.creator=Leon%2C+Olga+S.&rft.subject=Neurochemistry&rft.description=Several+studies+suggest+that+cyclooxygenase-2+contributes+to+the+delayed+progression+of+ischemic+brain+damage.+In+this+study+we+examined+whether+the+highly+selective+cyclooxygenase-2+inhibitor+DFU+reduces+neuronal+damage+when+administered+several+hours+after+5+min+of+transient+forebrain+ischemia+in+gerbils.+The+extent+of+ischemic+injury+was+assessed+behaviorally+by+measuring+the+increases+in+locomotor+activity+and+by+histopathological+evaluation+of+the+extent+of+CA1+hippocampal+pyramidal+cell+injury+7+days+after+ischemia.+DFU+treatment+(10+mg%2Fkg%2C+p.o.)+significantly+reduced+hippocampal+neuronal+damage+even+if+the+treatment+is+delayed+until+12+h+after+ischemia.+These+results+suggest+that+selective+cyclooxygenase-2+inhibitors+may+be+a+valuable+therapeutic+strategy+for+ischemic+brain+injury.&rft.publisher=Elsevier&rft.contributor=Bloom%2C+Floyd&rft.date=2002&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5645%2F1%2FBrain_Res_2002_Candelario-Jalil_et_al.pdf&rft.identifier=++Candelario-Jalil%2C+Eduardo+and+Alvarez%2C+Dalia+and+Castaneda%2C+Juana+M.+and+Al-Dalain%2C+Saied+M.+and+Martinez-Sanchez%2C+Gregorio+and+Merino%2C+Nelson+and+Leon%2C+Olga+S.++(2002)+The+highly+selective+cyclooxygenase-2+inhibitor+DFU+is+neuroprotective+when+given+several+hours+after+transient+cerebral+ischemia+in+gerbils.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5645%2F