http://cogprints.org/5645/
The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils
Several studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase-2 inhibitor DFU reduces neuronal damage when administered several hours after 5 min of transient forebrain ischemia in gerbils. The extent of ischemic injury was assessed behaviorally by measuring the increases in locomotor activity and by histopathological evaluation of the extent of CA1 hippocampal pyramidal cell injury 7 days after ischemia. DFU treatment (10 mg/kg, p.o.) significantly reduced hippocampal neuronal damage even if the treatment is delayed until 12 h after ischemia. These results suggest that selective cyclooxygenase-2 inhibitors may be a valuable therapeutic strategy for ischemic brain injury.
Candelario-Jalil, Eduardo
Alvarez, Dalia
Castaneda, Juana M.
Al-Dalain, Saied M.
Martinez-Sanchez, Gregorio
Merino, Nelson
Leon, Olga S.
Neurochemistry
Eduardo
Candelario-Jalil
Dalia
Alvarez
Juana M.
Castaneda
Saied M.
Al-Dalain
Gregorio
Martinez-Sanchez
Nelson
Merino
Olga S.
Leon