TY  - GEN
ID  - cogprints5645
UR  - http://cogprints.org/5645/
A1  - Candelario-Jalil, Eduardo
A1  - Alvarez, Dalia
A1  - Castaneda, Juana M.
A1  - Al-Dalain, Saied M.
A1  - Martinez-Sanchez, Gregorio
A1  - Merino, Nelson
A1  - Leon, Olga S.
Y1  - 2002///
N2  - Several studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase-2 inhibitor DFU reduces neuronal damage when administered several hours after 5 min of transient forebrain ischemia in gerbils. The extent of ischemic injury was assessed behaviorally by measuring the increases in locomotor activity and by histopathological evaluation of the extent of CA1 hippocampal pyramidal cell injury 7 days after ischemia. DFU treatment (10 mg/kg, p.o.) significantly reduced hippocampal neuronal damage even if the treatment is delayed until 12 h after ischemia. These results suggest that selective cyclooxygenase-2 inhibitors may be a valuable therapeutic strategy for ischemic brain injury.
PB  - Elsevier
KW  - cyclooxygenase-2; cerebral ischemia; neuroprotection; hippocampus; gerbil; DFU; prostaglandin E2; stroke; brain 
TI  - The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils
SP  - 212
AV  - public
EP  - 215
ER  -

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