?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Effects+of+pyruvate+administration+on+infarct+volume+and+neurological+deficits+following+permanent+focal+cerebral+ischemia+in+rats&rft.creator=Gonzalez-Falcon%2C+Armando&rft.creator=Candelario-Jalil%2C+Eduardo&rft.creator=Garcia-Cabrera%2C+Michel&rft.creator=Leon%2C+Olga+S.&rft.subject=Neurochemistry&rft.description=Recent+experimental+evidences+indicate+that+pyruvate%2C+the+final+metabolite+of+glycolysis%2C+has+a+remarkable+protective+effect+against+different+types+of+brain+injury.+The+purpose+of+this+study+was+to+assess+the+neuroprotective+effect+and+the+neurological+outcome+after+pyruvate+administration+in+a+model+of+ischemic+stroke+induced+by+permanent+middle+cerebral+artery+occlusion+(pMCAO)+in+rats.+Three+doses+of+pyruvate+(250%2C+500+and+1000+mg%2Fkg%2C+i.p.)+or+vehicle+were+administered+intraperitoneally+30+min+after+pMCAO.+In+other+set+of+experiments%2C+pyruvate+was+given+either+before%2C+immediately+after+ischemia+or+in+a+long-term+administration+paradigm.+Functional+outcome%2C+mortality+and+infarct+volume+were+determined+24+h+after+stroke.+Even+when+the+lowest+doses+of+pyruvate+reduced+mortality+and+neurological+deficits%2C+no+concomitant+reduction+in+infarct+volume+was+observed.+The+highest+dose+of+pyruvate+increased+cortical+infarction+by+27%25+when+administered+30+min+after+pMCAO.+In+addition%2C+when+pyruvate+was+given+before+pMCAO%2C+a+significant+increase+in+neurological+deficits+was+noticed.+Surprisingly%2C+on+the+contrary+of+what+was+found+in+the+case+of+transient+global+ischemia%2C+present+findings+do+not+support+a+great+neuroprotective+role+for+pyruvate+in+permanent+focal+cerebral+ischemia%2C+suggesting+two+distinct+mechanisms+involved+in+the+effects+of+this+glycolytic+metabolite+in+the+ischemic+brain.&rft.publisher=Elsevier&rft.date=2003-11&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5652%2F1%2Fpyruvate_in_stroke_Brain_Res_2003.pdf&rft.identifier=++Gonzalez-Falcon%2C+Armando+and+Candelario-Jalil%2C+Eduardo+and+Garcia-Cabrera%2C+Michel+and+Leon%2C+Olga+S.++(2003)+Effects+of+pyruvate+administration+on+infarct+volume+and+neurological+deficits+following+permanent+focal+cerebral+ischemia+in+rats.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5652%2F