@misc{cogprints5653, volume = {390}, number = {3}, month = {March}, author = {Eduardo Candelario-Jalil and Hussam Ajamieh and Susana Sam and Gregorio Martinez and Olga S. Leon}, title = {Nimesulide limits kainate-induced oxidative damage in the rat hippocampus}, publisher = {Elsevier}, year = {2000}, journal = {European Journal of Pharmacology}, pages = {295--298}, keywords = {kainate; excitotoxicity; cyclooxygenase-2; nimesulide; oxidative stress; hippocampus}, url = {http://cogprints.org/5653/}, abstract = {Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus. A clinically relevant dose of nimesulide (6 mg/kg, i.p. ) was administered three times following kainate application (9 mg/kg, i.p.). After 24 h of kainate administration, the drastic decrease in hippocampal glutathione content and the significant increase in lipid peroxidation were attenuated in nimesulide-treated rats, suggesting that the induction of cyclooxygenase-2 is involved in kainate-mediated free radicals formation.} }