title: Nimesulide limits kainate-induced oxidative damage in the rat hippocampus
creator: Candelario-Jalil, Eduardo
creator: Ajamieh, Hussam
creator: Sam, Susana
creator: Martinez, Gregorio
creator: Leon, Olga S.
subject: Neurochemistry
description: Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus. A clinically relevant dose of nimesulide (6 mg/kg, i.p. ) was administered three times following kainate application (9 mg/kg, i.p.). After 24 h of kainate administration, the drastic decrease in hippocampal glutathione content and the significant increase in lipid peroxidation were attenuated in nimesulide-treated rats, suggesting that the induction of cyclooxygenase-2 is involved in kainate-mediated free radicals formation.
publisher: Elsevier
date: 2000-03
type: Journal (Paginated)
type: PeerReviewed
format: application/pdf
identifier: http://cogprints.org/5653/1/Kainate_nimesulide_Eur_J_Pharmacol_2000.pdf
identifier:   Candelario-Jalil, Eduardo and Ajamieh, Hussam and Sam, Susana and Martinez, Gregorio and Leon, Olga S.  (2000) Nimesulide limits kainate-induced oxidative damage in the rat hippocampus.  [Journal (Paginated)]     
relation: http://cogprints.org/5653/