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"Nimesulide limits kainate-induced oxidative damage in the rat hippocampus"^^ .
"Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus. A clinically relevant dose of nimesulide (6 mg/kg, i.p. ) was administered three times following kainate application (9 mg/kg, i.p.). After 24 h of kainate administration, the drastic decrease in hippocampal glutathione content and the significant increase in lipid peroxidation were attenuated in nimesulide-treated rats, suggesting that the induction of cyclooxygenase-2 is involved in kainate-mediated free radicals formation."^^ .
"2000-03" .
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"390" .
"3" .
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"Elsevier"^^ .
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"European Journal of Pharmacology"^^ .
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"Eduardo"^^ .
"Candelario-Jalil"^^ .
"Eduardo Candelario-Jalil"^^ .
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"Olga S."^^ .
"Leon"^^ .
"Olga S. Leon"^^ .
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"Hussam"^^ .
"Ajamieh"^^ .
"Hussam Ajamieh"^^ .
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"Susana"^^ .
"Sam"^^ .
"Susana Sam"^^ .
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"Gregorio"^^ .
"Martinez"^^ .
"Gregorio Martinez"^^ .
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"Nimesulide limits kainate-induced oxidative damage in the rat hippocampus (PDF)"^^ .
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"Kainate_nimesulide_Eur_J_Pharmacol_2000.pdf"^^ .
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"Nimesulide limits kainate-induced oxidative damage in the rat hippocampus (Image (PNG))"^^ .
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"preview.png"^^ .
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"Nimesulide limits kainate-induced oxidative damage in the rat hippocampus (Indexer Terms)"^^ .
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"indexcodes.txt"^^ .
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