<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Nimesulide limits kainate-induced oxidative damage in the rat hippocampus"^^ . "Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus. A clinically relevant dose of nimesulide (6 mg/kg, i.p. ) was administered three times following kainate application (9 mg/kg, i.p.). After 24 h of kainate administration, the drastic decrease in hippocampal glutathione content and the significant increase in lipid peroxidation were attenuated in nimesulide-treated rats, suggesting that the induction of cyclooxygenase-2 is involved in kainate-mediated free radicals formation."^^ . "2000-03" . . "390" . "3" . . "Elsevier"^^ . . . "European Journal of Pharmacology"^^ . . . . . . . . . . . . . . . . . . . . "Eduardo"^^ . "Candelario-Jalil"^^ . "Eduardo Candelario-Jalil"^^ . . "Olga S."^^ . "Leon"^^ . "Olga S. Leon"^^ . . "Hussam"^^ . "Ajamieh"^^ . "Hussam Ajamieh"^^ . . "Susana"^^ . "Sam"^^ . "Susana Sam"^^ . . "Gregorio"^^ . "Martinez"^^ . "Gregorio Martinez"^^ . . . . . . "Nimesulide limits kainate-induced oxidative damage in the rat hippocampus (PDF)"^^ . . . . . . . . . "Kainate_nimesulide_Eur_J_Pharmacol_2000.pdf"^^ . . . "Nimesulide limits kainate-induced oxidative damage in the rat hippocampus (Image (PNG))"^^ . . . . . . "preview.png"^^ . . . "Nimesulide limits kainate-induced oxidative damage in the rat hippocampus (Indexer Terms)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #5653 \n\nNimesulide limits kainate-induced oxidative damage in the rat hippocampus\n\n" . "text/html" . . . "Neurochemistry" . .