TY  - GEN
ID  - cogprints5653
UR  - http://cogprints.org/5653/
A1  - Candelario-Jalil, Eduardo
A1  - Ajamieh, Hussam
A1  - Sam, Susana
A1  - Martinez, Gregorio
A1  - Leon, Olga S.
Y1  - 2000/03//
N2  - Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus. A clinically relevant dose of nimesulide (6 mg/kg, i.p. ) was administered three times following kainate application (9 mg/kg, i.p.). After 24 h of kainate administration, the drastic decrease in hippocampal glutathione content and the significant increase in lipid peroxidation were attenuated in nimesulide-treated rats, suggesting that the induction of cyclooxygenase-2 is involved in kainate-mediated free radicals formation.
PB  - Elsevier
KW  - kainate; excitotoxicity; cyclooxygenase-2; nimesulide; oxidative stress; hippocampus
TI  - Nimesulide limits kainate-induced oxidative damage in the rat hippocampus
SP  - 295
AV  - public
EP  - 298
ER  -

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