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TY - GEN ID - cogprints5653 UR - http://cogprints.org/5653/ A1 - Candelario-Jalil, Eduardo A1 - Ajamieh, Hussam A1 - Sam, Susana A1 - Martinez, Gregorio A1 - Leon, Olga S. Y1 - 2000/03// N2 - Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus. A clinically relevant dose of nimesulide (6 mg/kg, i.p. ) was administered three times following kainate application (9 mg/kg, i.p.). After 24 h of kainate administration, the drastic decrease in hippocampal glutathione content and the significant increase in lipid peroxidation were attenuated in nimesulide-treated rats, suggesting that the induction of cyclooxygenase-2 is involved in kainate-mediated free radicals formation. PB - Elsevier KW - kainate; excitotoxicity; cyclooxygenase-2; nimesulide; oxidative stress; hippocampus TI - Nimesulide limits kainate-induced oxidative damage in the rat hippocampus SP - 295 AV - public EP - 298 ER -