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--- abstract: 'Kainate induces a marked expression of cyclooxygenase-2 after its systemic administration. Because cyclooxygenase-2 activity is associated to the production of reactive oxygen species, we investigated the effects of nimesulide, a selective cyclooxygenase-2 inhibitor, on kainate-induced in vivo oxidative damage in the rat hippocampus. A clinically relevant dose of nimesulide (6 mg/kg, i.p. ) was administered three times following kainate application (9 mg/kg, i.p.). After 24 h of kainate administration, the drastic decrease in hippocampal glutathione content and the significant increase in lipid peroxidation were attenuated in nimesulide-treated rats, suggesting that the induction of cyclooxygenase-2 is involved in kainate-mediated free radicals formation.' altloc: - http://candelariojalil.googlepages.com/Eur_J_Pharmacol_Candelario-Jalil_et_al_2000.pdf chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: [] creators_name: - family: Candelario-Jalil given: Eduardo honourific: '' lineage: '' - family: Ajamieh given: Hussam honourific: '' lineage: '' - family: Sam given: Susana honourific: '' lineage: '' - family: Martinez given: Gregorio honourific: '' lineage: '' - family: Leon given: Olga S. honourific: '' lineage: '' date: 2000-03 date_type: published datestamp: 2007-08-20 department: ~ dir: disk0/00/00/56/53 edit_lock_since: ~ edit_lock_until: ~ edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 5653 fileinfo: /style/images/fileicons/application_pdf.png;/5653/1/Kainate_nimesulide_Eur_J_Pharmacol_2000.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: kainate; excitotoxicity; cyclooxygenase-2; nimesulide; oxidative stress; hippocampus lastmod: 2011-03-11 08:56:56 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 3 pagerange: 295-298 pubdom: FALSE publication: European Journal of Pharmacology publisher: Elsevier refereed: TRUE referencetext: | Adams, J., Colla�o-Moraes, Y., de Belleroche, J., 1996. 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Sperk, G., Lassmann, H., Baran, H., Seitelberger, F., Hornykiewicz, O., 1985. Kainic acid-induced seizures: dose-relationship of behavioral, neurochemical and histopathological changes. Brain Res. 338, 289-295. relation_type: [] relation_uri: [] reportno: ~ rev_number: 12 series: ~ source: ~ status_changed: 2007-09-12 17:11:16 subjects: - neuro-chem succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: Nimesulide limits kainate-induced oxidative damage in the rat hippocampus type: journalp userid: 6903 volume: 390