?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Selective+vulnerability+to+kainate-induced+oxidative+damage+in+different+rat+brain+regions&rft.creator=Candelario-Jalil%2C+Eduardo&rft.creator=Al-Dalain%2C+Saied+M.&rft.creator=Castillo%2C+Ruben&rft.creator=Martinez%2C+Gregorio&rft.creator=Leon%2C+Olga+S.&rft.subject=Neurochemistry&rft.description=Some+markers+of+oxidative+injury+were+measured+in+different+rat+brain+areas+(hippocampus%2C+cerebral+cortex%2C+striatum%2C+hypothalamus%2C+amygdala%2Fpiriform+cortex+and+cerebellum)+after+the+systemic+administration+of+an+excitotoxic+dose+of+kainic+acid+(KA%2C+9+mg+kg(-1)+i.p.)+at+two+different+sampling+times+(24+and+48+h).+Kainic+acid+was+able+to+lower+markedly+(P+%3C+0.05)+the+glutathione+(GSH)+levels+in+hippocampus%2C+cerebellum+and+amygdala%2Fpiriform+cortex+(maximal+reduction+at+24+h).+In+a+similar+way%2C+lipid+peroxidation%2C+as+assessed+by+malonaldehyde+and+4-hydroxyalkenal+levels%2C+significantly+increased+(P+%3C+0.05)+in+hippocampus%2C+cerebellum+and+amygdala%2Fpiriform+cortex+mainly+at+24+h+after+KA.+In+addition%2C+hippocampal+superoxide+dismutase+(SOD)+activity+decreased+significantly+(P+%3C+0.05)+with+respect+to+basal+levels+by+24+h+after+KA+application.+On+the+other+hand%2C+brain+areas+such+as+hypothalamus%2C+striatum+and+cerebral+cortex+seem+to+be+less+susceptible+to+KA+excitotoxicity.+According+to+these+findings%2C+the+pattern+of+oxidative+injury+induced+by+systemically+administered+KA+seems+to+be+highly+region-specific.+Further%2C+our+results+have+shown+that+a+lower+antioxidant+status+(GSH+and+SOD)+seems+not+to+play+an+important+role+in+the+selective+vulnerability+of+certain+brain+regions+because+it+correlates+poorly+with+increases+in+markers+of+oxidative+damage.&rft.publisher=John+Wiley+%26+Sons%2C+Ltd.&rft.date=2001&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5667%2F1%2Fkainic_acid_oxidative_stress_J_Appl_Toxicol_2001.pdf&rft.identifier=++Candelario-Jalil%2C+Eduardo+and+Al-Dalain%2C+Saied+M.+and+Castillo%2C+Ruben+and+Martinez%2C+Gregorio+and+Leon%2C+Olga+S.++(2001)+Selective+vulnerability+to+kainate-induced+oxidative+damage+in+different+rat+brain+regions.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5667%2F