?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Antiallergic+Activity+of+Substituted+Benzamides%3A+Characterization%2C+Estimation+and+Prediction&rft.creator=J%C3%84NTSCHI%2C+Dr.+Lorentz&rft.creator=BOLBOACA%2C+Dr.+Sorana+D.&rft.subject=Statistical+Models&rft.description=Antiallergic+activity+of+twenty-three+substituted+N+4-methoxyphenyl+benzamides+was+model+by+the+use+of+an+original+methodology.+After+sketching+out+the+compounds+structure+and+creating+the+file+with+the+observed+activities%2C+strictly+based+on+compounds+structure%2C+the+molecular+descriptors+family+was+generated+and+descriptors+entered+into+a+multiple+linear+regression+analysis.+The+multi-varied+model+with+four+descriptors+proved+to+render+higher+ability+in+estimation+(squared+correlation+coefficient%2C+r2+%3D+0.9986)+as+well+as+in+prediction+(cross-validation+leave-one-out+score%2C+r2cv-loo+%3D+0.9956)+of+antiallergic+activity+of+compounds%2C+obtained+significantly+greater+correlation+coefficient+compared+with+the+previously+reported+model+(p+%3C+0.01).+Characterization+of+antiallergic+activity+of+substituted+N+4-methoxyphenyl+benzamides+by+integration+of+complex+structure+information+provides+a+stable+and+efficient+multi-varied+model+with+four+descriptors.+According+with+the+multi-varied+model+with+four+descriptors+the+antiallergic+activity+of+substituted+N+4-methoxyphenyl+benzamides+is+like+to+be+of+geometry+nature%2C+depending+by+the+number+of+directly+bonded+hydrogen%E2%80%99s%2C+and+the+atomic+relative+mass%2C+being+in+relation+with+the+partial+charge+of+compounds.&rft.publisher=Editura+U.M.F.+Iuliu+Hatieganu+Cluj+Napoca&rft.contributor=OLINIC%2C+Prof.+Dr.+Nour+C.&rft.date=2007-06-01&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5744%2F1%2Fwork_list.pdf&rft.identifier=++J%C3%84NTSCHI%2C+Dr.+Lorentz+and+BOLBOACA%2C+Dr.+Sorana+D.++(2007)+Antiallergic+Activity+of+Substituted+Benzamides%3A+Characterization%2C+Estimation+and+Prediction.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5744%2F