?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Lack+of+analgesic+efficacy+in+female+rats+of%0D%0Athe+commonly+recommended+oral+dose+of%0D%0Abuprenorphine&rft.creator=Thompson%2C+Dr.+Alexis+C.&rft.creator=DiPirro%2C+Dr.+Jean+M.&rft.creator=Sylvester%2C+Mr.+Ahmad+R.&rft.creator=Martin%2C+Dr.+Lisa+B.E.&rft.creator=Kristal%2C+Dr.+Mark+B.&rft.subject=Neuropharmacology&rft.description=Previous+work+in+our+laboratory+showed+that+the+recommended+oral+dose+of+buprenorphine+(0.5+mg%2Fkg)+was+not+as+effective%0D%0Aas+the+standard+therapeutic+subcutaneous+dose+for+postoperative+analgesia+in+male+Long-Evans+(hooded)+and+Sprague-Dawley+(albino)+rats.+The+aim+of+the+current+study+was+to+extend+this+analysis+to+female+rats.+We+measured+the+pain+threshold+in+adult+female+rats+in+diestrus+or+proestrus+before+and+30+and+60+min+after+oral+buprenorphine+(0.5+mg%2Fkg%2C)%2C+the+standard+subcutaneous+dose+of+buprenorphine+(0.05+mg%2Fkg)%2C+or+vehicle+only+(1+ml%2Fkg+each+orally+and+subcutaneously).+Female+rats+showed+an+increased+pain+threshold+(analgesia)+after+subcutaneous+buprenorphine+but+no+change+in+pain+threshold+after+either+oral+buprenorphine+or+vehicle+only.+Estrous+cycle+stage+(proestrus+versus+diestrus)+did+not+affect+the+analgesic+effects+of+buprenorphine%2C+but+rats+in+proestrus+showed+significantly+lower+pain+thresholds+(less+tolerance+to+pain)+than+did+those+in+diestrus.+These+results+show+that+the+oral+dose+of+buprenorphine+recommended+for+postoperative+analgesic+care+does+not+induce+significant+analgesia+in+female+rats+and+therefore+is+not+as+effective+as+the+standard+subcutaneous+dose.&rft.publisher=American+Association+for+Laboratory+Animal+Science&rft.date=2006-11&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5754%2F1%2FJAALAS.pdf&rft.identifier=++Thompson%2C+Dr.+Alexis+C.+and+DiPirro%2C+Dr.+Jean+M.+and+Sylvester%2C+Mr.+Ahmad+R.+and+Martin%2C+Dr.+Lisa+B.E.+and+Kristal%2C+Dr.+Mark+B.++(2006)+Lack+of+analgesic+efficacy+in+female+rats+of+the+commonly+recommended+oral+dose+of+buprenorphine.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5754%2F