---
abstract: "Previous work in our laboratory showed that the recommended oral dose of buprenorphine (0.5 mg/kg) was not as effective\r\nas the standard therapeutic subcutaneous dose for postoperative analgesia in male Long-Evans (hooded) and Sprague-Dawley (albino) rats. The aim of the current study was to extend this analysis to female rats. We measured the pain threshold in adult female rats in diestrus or proestrus before and 30 and 60 min after oral buprenorphine (0.5 mg/kg,), the standard subcutaneous dose of buprenorphine (0.05 mg/kg), or vehicle only (1 ml/kg each orally and subcutaneously). Female rats showed an increased pain threshold (analgesia) after subcutaneous buprenorphine but no change in pain threshold after either oral buprenorphine or vehicle only. Estrous cycle stage (proestrus versus diestrus) did not affect the analgesic effects of buprenorphine, but rats in proestrus showed significantly lower pain thresholds (less tolerance to pain) than did those in diestrus. These results show that the oral dose of buprenorphine recommended for postoperative analgesic care does not induce significant analgesia in female rats and therefore is not as effective as the standard subcutaneous dose."
altloc: []
chapter: ~
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contact_email: ~
creators_id:
  - ''
  - ''
  - ''
  - ''
  - kristal@buffalo.edu
creators_name:
  - family: Thompson
    given: Alexis C.
    honourific: Dr.
    lineage: ''
  - family: DiPirro
    given: Jean M.
    honourific: Dr.
    lineage: ''
  - family: Sylvester
    given: Ahmad R.
    honourific: Mr.
    lineage: ''
  - family: Martin
    given: Lisa B.E.
    honourific: Dr.
    lineage: ''
  - family: Kristal
    given: Mark B.
    honourific: Dr.
    lineage: ''
date: 2006-11
date_type: published
datestamp: 2007-10-15 11:31:04
department: ~
dir: disk0/00/00/57/54
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editors_id: []
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eprint_status: archive
eprintid: 5754
fileinfo: /style/images/fileicons/application_pdf.png;/5754/1/JAALAS.pdf
full_text_status: public
importid: ~
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ispublished: pub
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item_issues_count: 0
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item_issues_resolved_by: []
item_issues_status: []
item_issues_timestamp: []
item_issues_type: []
keywords: 'buprenorphine, analgesia, pain, rat'
lastmod: 2011-03-11 08:56:58
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: 6
pagerange: 13-16
pubdom: FALSE
publication: Journal of the American Association for Laboratory Animal Science
publisher: American Association for Laboratory Animal Science
refereed: TRUE
referencetext: ~
relation_type: []
relation_uri: []
reportno: ~
rev_number: 22
series: ~
source: ~
status_changed: 2007-10-15 11:31:04
subjects:
  - neuro-pharm
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: "Lack of analgesic efficacy in female rats of\r\nthe commonly recommended oral dose of\r\nbuprenorphine"
type: journalp
userid: 88
volume: 45
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