?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Analgesic+efficacy+of+orally+administered%0D%0Abuprenorphine+in+rats%3A+methodologic%0D%0Aconsiderations&rft.creator=Thompson%2C+Dr.+Alexis+C.&rft.creator=Kristal%2C+Dr.+Mark+B.&rft.creator=Sallaj%2C+Mr.+Abdullah&rft.creator=Acheson%2C+Mr.+Ashley&rft.creator=Martin%2C+Dr.+Lisa+B.E.&rft.creator=Martin%2C+Dr.+Thomas&rft.subject=Neuropharmacology&rft.description=Buprenorphine+has+been+widely+recommended+for+treatment+of+pain+in+rodents.+We+have+previously+documented+that+the+recommended+postoperative+oral+dose+of+buprenorphine+in+male+Long-Evans+rats%2C+0.5+mg%2Fkg%2C+is+not+as+effective+as+the+recommended+parenteral+dose+of+buprenorphine+(0.05+mg%2Fkg%2C+s.c.)+as+an+analgesic+(21).+In+the+series+of+experiments+reported+here%2C+we+compared%3A+the+analgesic+effect+of+buprenorphine+when+prepared+in+two+ways+in+the+laboratory+with+that+of+a+commercially+available+injectable+solution+of+buprenorphine%3B+the+analgesic+effect+of+buprenorphine+in+Long-Evans+rats+with+that+in+Sprague-Dawley+rats%3B+and+Long-Evans+and+Sprague-Dawley+rats+for+development+of+pica%2C+a+commonly+reported+side+effect+of+buprenorphine.+We+followed+the+pica+experiment+with+assessment+of+the+effectiveness+of+buprenorphine+in+establishing+a+conditioned+flavor+aversion.+The+results+indicated+that+method+of+preparation+did+not+result+in+any+significant+differences+in+the+efficacy+of+injected+buprenorphine.+Strain+of+rat+was+not+associated+with+a+significant+difference+in+the+efficacy+of+buprenorphine.+However%2C+a+significant+strain+difference+was+found+in+development+of+pica.+Buprenorphine+treatment+was+effective+in+inducing+a+conditioned+flavor+aversion.+We+concluded+that+the+recommended+oral+dose+of+buprenorphine+(0.5+mg%2Fkg)+is+ineffective+as+an+analgesic%2C+and+that+this+was+not+the+result+of+method+of+preparation+of+the+buprenorphine+or+strain+of+rat+used.+Furthermore%2C+we%0D%0Aconcluded+that+buprenorphine+treatment+may+induce+gastrointestinal+distress+in+both+strains+tested.+The+results+reaffirm+our+previous+conclusion+that+oral+administration+of+buprenorphine+at+0.5+mg%2Fkg%2C+despite+the+general+recommendation%2C+is+not+a+reasonable+treatment+for+postsurgical+pain+in+rats.&rft.publisher=American+Association+for+Laboratory+Animal+Science&rft.date=2004-06&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5755%2F1%2FThompson_buprenorphine.pdf&rft.identifier=++Thompson%2C+Dr.+Alexis+C.+and+Kristal%2C+Dr.+Mark+B.+and+Sallaj%2C+Mr.+Abdullah+and+Acheson%2C+Mr.+Ashley+and+Martin%2C+Dr.+Lisa+B.E.+and+Martin%2C+Dr.+Thomas++(2004)+Analgesic+efficacy+of+orally+administered+buprenorphine+in+rats%3A+methodologic+considerations.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5755%2F