TY  - GEN
ID  - cogprints5763
UR  - http://cogprints.org/5763/
A1  - Abbott, P.
A1  - Thompson, A. C.
A1  - Ferguson, E.J.
A1  - Doerr, J. C.
A1  - Tarapacki, J. A.
A1  - Kostyniak, Dr. P.J.
A1  - Syracuse, J.A.
A1  - Cartonia, D.M.
A1  - Kristal, Dr. Mark B.
Y1  - 1991///
N2  - A substance in amniotic fluid and placenta (POEF for Placental Opioid-Enhancing Factor) has been shown to enhance opiate- or opioid-mediated analgesia in rats. Recent studies have only touched on the generalizability of the phenomenon. The present studies further tested the generalizability of the POEF effect: they examined sex specificity of the mechanism, whether POEF activity exists in afterbirth material of species other than the rat; whether POEF activity exists in tissue other than afterbirth material; whether POEF activity could be demonstrated after injection rather than ingestion of afterbirth material; and whether POEF enhances all opioid-mediated phenomena. We found that (a) POEF is effective in male rats as well as in female rats; (b) POEF activity exists in human and dolphin afterbirth material; (c) ingestion of pregnant-rat liver does not produce enhancement of opioid-mediated analgesia; (d) POEF does not seem to be effective when amniotic fluid is injected either IPO or SC; and (e) POEF does not modify morphine-induced hyperthermia.
PB  - Pergamon Press
KW  - POEF
KW  -  placenta
KW  -  analgesia
KW  -  opioids
KW  -  amniotic fluid
KW  -  pain
KW  -  morphine
KW  -  birth
KW  -  placentophagia
TI  - Placental opioid-enhancing factor (POEF): Generalizability of effects
SP  - 933
AV  - public
EP  - 940
ER  -

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