?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Amniotic-fluid+ingestion+by+parturient+rats+enhances+pregnancy-mediated+analgesia&rft.creator=Kristal%2C+Dr.+Mark+B.&rft.creator=Thompson%2C+Alexis+C.&rft.creator=Abbott%2C+P.&rft.creator=DiPirro%2C+Jean+M.&rft.creator=Ferguson%2C+E.J.&rft.creator=Doerr%2C+J.+C.&rft.subject=Psychobiology&rft.subject=Neuropharmacology&rft.subject=Behavioral+Neuroscience&rft.description=Amniotic+fluid+and+placenta+contain+a+substance+(POEF%2C+for+Placental+Opioid-Enhancing+Factor)+that%2C+when+ingested%2C+enhances+opioid-mediated+analgesia+in+nonpregnant+rats%3B+ingestion+of+the+substance+by+rats+not+experiencing+opioid-mediated+analgesia%2C+however%2C+does+not+produce+analgesia.+It+is+highly+likely+that+periparturitional+analgesia-enhancement+is+a+significant+benefit+of+ingestion+of+the+afterbirth+(placentophagia)+during+delivery.+Here+we+report+that+prepartum+ingestion+of+amniotic+fluid+(via+orogastric+infusion)+does+indeed+enhance+the+endogenous-opioid-mediated+analgesia+evident+at+the+end+of+pregnancy+and+during+delivery%3B+that+the+degree+of+enhancement+is+greater+with+0.75+ml+than+with+0.25+ml%2C+and+that+the+prepartum+enhancement+of+analgesia+can+be+blocked+with+the+opioid+antagonist+naloxone.&rft.publisher=Pergamon+Press&rft.date=1990&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5769%2F1%2Fls.pdf&rft.identifier=++Kristal%2C+Dr.+Mark+B.+and+Thompson%2C+Alexis+C.+and+Abbott%2C+P.+and+DiPirro%2C+Jean+M.+and+Ferguson%2C+E.J.+and+Doerr%2C+J.+C.++(1990)+Amniotic-fluid+ingestion+by+parturient+rats+enhances+pregnancy-mediated+analgesia.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5769%2F