"5769","Amniotic-fluid ingestion by parturient rats enhances pregnancy-mediated analgesia","Amniotic fluid and placenta contain a substance (POEF, for Placental Opioid-Enhancing Factor) that, when ingested, enhances opioid-mediated analgesia in nonpregnant rats; ingestion of the substance by rats not experiencing opioid-mediated analgesia, however, does not produce analgesia. It is highly likely that periparturitional analgesia-enhancement is a significant benefit of ingestion of the afterbirth (placentophagia) during delivery. Here we report that prepartum ingestion of amniotic fluid (via orogastric infusion) does indeed enhance the endogenous-opioid-mediated analgesia evident at the end of pregnancy and during delivery; that the degree of enhancement is greater with 0.75 ml than with 0.25 ml, and that the prepartum enhancement of analgesia can be blocked with the opioid antagonist naloxone.","http://cogprints.org/5769/","Kristal, Dr. Mark B. and Thompson, Alexis C. and Abbott, P. and DiPirro, Jean M. and Ferguson, E.J. and Doerr, J. C.","UNSPECIFIED","       <span class=\"person_name\">Kristal, Dr. Mark B.</span> and <span class=\"person_name\">Thompson, Alexis C.</span> and <span class=\"person_name\">Abbott, P.</span> and <span class=\"person_name\">DiPirro, Jean M.</span> and <span class=\"person_name\">Ferguson, E.J.</span> and <span class=\"person_name\">Doerr, J. C.</span>     (1990)  <a href=\"http://cogprints.org/5769/\"><em>Amniotic-fluid ingestion by parturient rats enhances pregnancy-mediated analgesia.</em></a>       [Journal (Paginated)]           ","kristal@buffalo.edu,,,,,","1990"