creators_name: Kristal, Mark B.
creators_name: Thompson, Alexis C.
creators_name: Abbott, P.
creators_name: DiPirro, Jean M.
creators_name: Ferguson, E.J.
creators_name: Doerr, J. C.
creators_id: kristal@buffalo.edu
creators_id: 
creators_id: 
creators_id: 
creators_id: 
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type: journalp
datestamp: 2007-10-22 10:44:38
lastmod: 2011-03-11 08:56:59
metadata_visibility: show
title: Amniotic-fluid ingestion by parturient rats enhances pregnancy-mediated analgesia
ispublished: pub
subjects: psy-bio
subjects: neuro-pharm
subjects: behav-neuro-sci
full_text_status: public
keywords: placentophagia, POEF, amniotic fluid, analgesia, pain, delivery, parturition, rat
abstract: Amniotic fluid and placenta contain a substance (POEF, for Placental Opioid-Enhancing Factor) that, when ingested, enhances opioid-mediated analgesia in nonpregnant rats; ingestion of the substance by rats not experiencing opioid-mediated analgesia, however, does not produce analgesia. It is highly likely that periparturitional analgesia-enhancement is a significant benefit of ingestion of the afterbirth (placentophagia) during delivery. Here we report that prepartum ingestion of amniotic fluid (via orogastric infusion) does indeed enhance the endogenous-opioid-mediated analgesia evident at the end of pregnancy and during delivery; that the degree of enhancement is greater with 0.75 ml than with 0.25 ml, and that the prepartum enhancement of analgesia can be blocked with the opioid antagonist naloxone.
date: 1990
date_type: published
publication: Life Sciences
volume: 46
number: 10
publisher: Pergamon Press
pagerange: 693-698
refereed: TRUE
citation:   Kristal, Dr. Mark B. and Thompson, Alexis C. and Abbott, P. and DiPirro, Jean M. and Ferguson, E.J. and Doerr, J. C.  (1990) Amniotic-fluid ingestion by parturient rats enhances pregnancy-mediated analgesia.  [Journal (Paginated)]     
document_url: http://cogprints.org/5769/1/ls.pdf