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--- abstract: 'Amniotic fluid and placenta contain a substance (POEF, for Placental Opioid-Enhancing Factor) that, when ingested, enhances opioid-mediated analgesia in nonpregnant rats; ingestion of the substance by rats not experiencing opioid-mediated analgesia, however, does not produce analgesia. It is highly likely that periparturitional analgesia-enhancement is a significant benefit of ingestion of the afterbirth (placentophagia) during delivery. Here we report that prepartum ingestion of amniotic fluid (via orogastric infusion) does indeed enhance the endogenous-opioid-mediated analgesia evident at the end of pregnancy and during delivery; that the degree of enhancement is greater with 0.75 ml than with 0.25 ml, and that the prepartum enhancement of analgesia can be blocked with the opioid antagonist naloxone.' altloc: [] chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - kristal@buffalo.edu - '' - '' - '' - '' - '' creators_name: - family: Kristal given: Mark B. honourific: Dr. lineage: '' - family: Thompson given: Alexis C. honourific: '' lineage: '' - family: Abbott given: P. honourific: '' lineage: '' - family: DiPirro given: Jean M. honourific: '' lineage: '' - family: Ferguson given: E.J. honourific: '' lineage: '' - family: Doerr given: J. C. honourific: '' lineage: '' date: 1990 date_type: published datestamp: 2007-10-22 10:44:38 department: ~ dir: disk0/00/00/57/69 edit_lock_since: ~ edit_lock_until: ~ edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 5769 fileinfo: /style/images/fileicons/application_pdf.png;/5769/1/ls.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'placentophagia, POEF, amniotic fluid, analgesia, pain, delivery, parturition, rat' lastmod: 2011-03-11 08:56:59 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 10 pagerange: 693-698 pubdom: FALSE publication: Life Sciences publisher: Pergamon Press refereed: TRUE referencetext: ~ relation_type: [] relation_uri: [] reportno: ~ rev_number: 25 series: ~ source: ~ status_changed: 2007-10-22 10:44:37 subjects: - psy-bio - neuro-pharm - behav-neuro-sci succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: Amniotic-fluid ingestion by parturient rats enhances pregnancy-mediated analgesia type: journalp userid: 88 volume: 46