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"Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception"^^ .
"Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (m, d, k) in the antinociception-modulating effects of Placental Opioid-Enhancing Factor (POEF—presumably the active substance). Antinociception was measured on a 52 C hotplate in adult, female rats after they ingested placenta or control substance (1.0 g) and after they received an intracerebroventricular injection of a d-specific ([D-Pen2,D-Pen5]enkephalin (DPDPE); 0, 30, 50, 62, or 70 nmol), m-specific ([D-Ala2,N-MePhe4,Gly5-ol]enkephalin (DAMGO); 0, 0.21, 0.29, or 0.39 nmol), or k-specific\r\n(U-62066; spiradoline; 0, 100, 150, or 200 nmol) opioid receptor agonist. The results showed that ingestion of placenta potentiated d- and k-opioid antinociception, but attenuated m-opioid antinociception. This finding of POEF action as both opioid receptor-specific and complex\r\nprovides an important basis for understanding the intrinsic pain-suppression mechanisms that are activated during parturition and modified by placentophagia, and important information for the possible use of POEF as an adjunct to opioids in pain management."^^ .
"2004" .
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"1014" .
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"Elsevier"^^ .
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"Brain Research"^^ .
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"Mark B."^^ .
"Kristal"^^ .
"Mark B. Kristal"^^ .
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"Jean M."^^ .
"DiPirro"^^ .
"Jean M. DiPirro"^^ .
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"Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception (PDF)"^^ .
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"DiPirro_and_Kristal.pdf"^^ .
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"Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception (Image (PNG))"^^ .
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"Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception (Indexer Terms)"^^ .
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"indexcodes.txt"^^ .
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"HTML Summary of #5771 \n\nPlacenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception\n\n" .
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"Psychobiology" .
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"Neuropharmacology" .
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"Behavioral Neuroscience" .
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