This site has been permanently archived. This is a static copy provided by the University of Southampton.

<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception"^^ . "Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (m, d, k) in the antinociception-modulating effects of Placental Opioid-Enhancing Factor (POEF—presumably the active substance). Antinociception was measured on a 52 C hotplate in adult, female rats after they ingested placenta or control substance (1.0 g) and after they received an intracerebroventricular injection of a d-specific ([D-Pen2,D-Pen5]enkephalin (DPDPE); 0, 30, 50, 62, or 70 nmol), m-specific ([D-Ala2,N-MePhe4,Gly5-ol]enkephalin (DAMGO); 0, 0.21, 0.29, or 0.39 nmol), or k-specific\r\n(U-62066; spiradoline; 0, 100, 150, or 200 nmol) opioid receptor agonist. The results showed that ingestion of placenta potentiated d- and k-opioid antinociception, but attenuated m-opioid antinociception. This finding of POEF action as both opioid receptor-specific and complex\r\nprovides an important basis for understanding the intrinsic pain-suppression mechanisms that are activated during parturition and modified by placentophagia, and important information for the possible use of POEF as an adjunct to opioids in pain management."^^ . "2004" . . "1014" . . "Elsevier"^^ . . . "Brain Research"^^ . . . . . . . . . . . "Mark B."^^ . "Kristal"^^ . "Mark B. Kristal"^^ . . "Jean M."^^ . "DiPirro"^^ . "Jean M. DiPirro"^^ . . . . . . "Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception (PDF)"^^ . . . . . . . . . "DiPirro_and_Kristal.pdf"^^ . . . "Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception (Image (PNG))"^^ . . . . . . "preview.png"^^ . . . "Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception (Indexer Terms)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #5771 \n\nPlacenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception\n\n" . "text/html" . . . "Psychobiology" . . . "Neuropharmacology" . . . "Behavioral Neuroscience" . .