This site has been permanently archived. This is a static copy provided by the University of Southampton.
TY - GEN
ID - cogprints5771
UR - http://cogprints.org/5771/
A1 - DiPirro, Jean M.
A1 - Kristal, Dr. Mark B.
Y1 - 2004///
N2 - Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (m, d, k) in the antinociception-modulating effects of Placental Opioid-Enhancing Factor (POEF?presumably the active substance). Antinociception was measured on a 52 C hotplate in adult, female rats after they ingested placenta or control substance (1.0 g) and after they received an intracerebroventricular injection of a d-specific ([D-Pen2,D-Pen5]enkephalin (DPDPE); 0, 30, 50, 62, or 70 nmol), m-specific ([D-Ala2,N-MePhe4,Gly5-ol]enkephalin (DAMGO); 0, 0.21, 0.29, or 0.39 nmol), or k-specific
(U-62066; spiradoline; 0, 100, 150, or 200 nmol) opioid receptor agonist. The results showed that ingestion of placenta potentiated d- and k-opioid antinociception, but attenuated m-opioid antinociception. This finding of POEF action as both opioid receptor-specific and complex
provides an important basis for understanding the intrinsic pain-suppression mechanisms that are activated during parturition and modified by placentophagia, and important information for the possible use of POEF as an adjunct to opioids in pain management.
PB - Elsevier
KW - placentophagia
KW - POEF
KW - antinociception
KW - opioid
KW - parturition
KW - DPDPE
KW - DAMGO
KW - spiradoline
KW - rat
KW - opioid receptor
KW - delta
KW - kappa
KW - mu
KW - pain
TI - Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception
SP - 22
AV - public
EP - 33
ER -