This site has been permanently archived. This is a static copy provided by the University of Southampton.
---
abstract: "Ingestion of placenta or amniotic fluid produces a dramatic enhancement of centrally mediated opioid antinociception in the rat. The present experiments investigated the role of each opioid receptor type (m, d, k) in the antinociception-modulating effects of Placental Opioid-Enhancing Factor (POEF—presumably the active substance). Antinociception was measured on a 52 C hotplate in adult, female rats after they ingested placenta or control substance (1.0 g) and after they received an intracerebroventricular injection of a d-specific ([D-Pen2,D-Pen5]enkephalin (DPDPE); 0, 30, 50, 62, or 70 nmol), m-specific ([D-Ala2,N-MePhe4,Gly5-ol]enkephalin (DAMGO); 0, 0.21, 0.29, or 0.39 nmol), or k-specific\r\n(U-62066; spiradoline; 0, 100, 150, or 200 nmol) opioid receptor agonist. The results showed that ingestion of placenta potentiated d- and k-opioid antinociception, but attenuated m-opioid antinociception. This finding of POEF action as both opioid receptor-specific and complex\r\nprovides an important basis for understanding the intrinsic pain-suppression mechanisms that are activated during parturition and modified by placentophagia, and important information for the possible use of POEF as an adjunct to opioids in pain management."
altloc: []
chapter: ~
commentary: ~
commref: ~
confdates: ~
conference: ~
confloc: ~
contact_email: ~
creators_id:
- ''
- kristal@buffalo.edu
creators_name:
- family: DiPirro
given: Jean M.
honourific: ''
lineage: ''
- family: Kristal
given: Mark B.
honourific: Dr.
lineage: ''
date: 2004
date_type: published
datestamp: 2007-10-22 10:43:55
department: ~
dir: disk0/00/00/57/71
edit_lock_since: ~
edit_lock_until: ~
edit_lock_user: ~
editors_id: []
editors_name: []
eprint_status: archive
eprintid: 5771
fileinfo: /style/images/fileicons/application_pdf.png;/5771/1/DiPirro_and_Kristal.pdf
full_text_status: public
importid: ~
institution: ~
isbn: ~
ispublished: pub
issn: ~
item_issues_comment: []
item_issues_count: 0
item_issues_description: []
item_issues_id: []
item_issues_reported_by: []
item_issues_resolved_by: []
item_issues_status: []
item_issues_timestamp: []
item_issues_type: []
keywords: 'placentophagia, POEF, antinociception, opioid, parturition, DPDPE, DAMGO, spiradoline, rat, opioid receptor, delta, kappa, mu, pain'
lastmod: 2011-03-11 08:56:59
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: ~
pagerange: 22-33
pubdom: FALSE
publication: Brain Research
publisher: Elsevier
refereed: TRUE
referencetext: ~
relation_type: []
relation_uri: []
reportno: ~
rev_number: 25
series: ~
source: ~
status_changed: 2007-10-22 10:43:55
subjects:
- psy-bio
- neuro-pharm
- behav-neuro-sci
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: 'Placenta ingestion by rats enhances d- and k-opioid antinociception, but suppresses m-opioid antinociception'
type: journalp
userid: 88
volume: 1014