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--- abstract: 'Ingestion of amniotic fluid or placenta by rats has been shown to enhance opioid-mediated analgesia induced by morphine injection, footshock, vaginal/cervical stimulation, or late pregnancy. This enhancement by ingestion appears to be specific to the central actions of opioids. The present study was designed to examine the possibility that information traveling via the vagus nerve might be involved in mediating this effect. Rats that had undergone either selective gastric vagotomy or sham vagotomy were injected with either morphine sulfate or vehicle and fed either placenta or a meat control. Enhancement was observed in rats that had undergone sham vagotomy but not in those that had undergone gastric vagotomy. These results support an interpretation of vagal involvement in the enhancement of opioid-mediated analgesia by placenta.' altloc: [] chapter: ~ commentary: ~ commref: ~ confdates: ~ conference: ~ confloc: ~ contact_email: ~ creators_id: - '' - '' - kristal@buffalo.edu creators_name: - family: Tarapacki given: J. A. honourific: '' lineage: '' - family: Thompson given: A. C. honourific: '' lineage: '' - family: Kristal given: Mark B. honourific: Dr. lineage: '' date: 1992 date_type: published datestamp: 2007-11-13 01:06:13 department: ~ dir: disk0/00/00/58/00 edit_lock_since: ~ edit_lock_until: ~ edit_lock_user: ~ editors_id: [] editors_name: [] eprint_status: archive eprintid: 5800 fileinfo: /style/images/fileicons/application_pdf.png;/5800/1/vagotomy.pdf full_text_status: public importid: ~ institution: ~ isbn: ~ ispublished: pub issn: ~ item_issues_comment: [] item_issues_count: 0 item_issues_description: [] item_issues_id: [] item_issues_reported_by: [] item_issues_resolved_by: [] item_issues_status: [] item_issues_timestamp: [] item_issues_type: [] keywords: 'placenta, opioids, morphine, POEF, vagotomy, placentophagia, pain, analgesia, antinociception, tail-flick latency, vagus, rat' lastmod: 2011-03-11 08:56:59 latitude: ~ longitude: ~ metadata_visibility: show note: ~ number: 1 pagerange: 179-182 pubdom: FALSE publication: Physiology & Behavior publisher: Pergamon Press refereed: TRUE referencetext: ~ relation_type: [] relation_uri: [] reportno: ~ rev_number: 23 series: ~ source: ~ status_changed: 2007-11-13 01:06:13 subjects: - physio-psy - behav-neuro-sci - neuro-chem succeeds: ~ suggestions: ~ sword_depositor: ~ sword_slug: ~ thesistype: ~ title: Gastric vagotomy blocks opioid analgesia enhancement produced by placenta ingestion type: journalp userid: 88 volume: 52