?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Conformational+Dynamics+and+Thermal+Cones+of+C-terminal+Tubulin+Tails+in+Neuronal+Microtubules&rft.creator=Georgiev%2C+Danko&rft.creator=Glazebrook%2C+James&rft.subject=Biophysics&rft.subject=Neurophysiology&rft.description=In+this+paper+we+present+a+model+for+estimation+of+the+C-terminal+tubulin+tail+(CTT)+dynamics+in+cytoskeletal+microtubules+of+nerve+cells.+We+show+that+the+screened+Coulomb+interaction+between+a+target+CTT+and+the+negatively+charged+microtubule+surface+as+well+as+its+immediate+CTT+neighbours+results+in+confinement+of+the+CTT+motion%0D%0Awithin+a+restricted+volume+referred+to+as+a+thermal+cone.+Within+the+thermal+cone+the+CTT+motion+is+driven+by+the+thermal+fluctuations%2C+while+outside+the+thermal+cone+the+CTT+interaction+energy+with+its+environment+is+above+the+thermal+energy+solely+due+to+repulsion+from+the+negatively+charged+microtubule+surface.+Computations+were+performed+for+different+CTT+geometries+and+we+have+found+that+the+CTT+conformation+with+lowest+energy+is+perpendicular+to+the+microtubule+surface.+Since+the+coupling+between+a+target+CTT+with+its+neighbour+CTTs+is+8+orders+of+magnitude+below+the+thermal+energy+and+considering+the+extremely+short+cytosolic+Debye+length+of+0.79+nm%2C+our+results+rule+out+generation%0D%0Aand+propagation+of+CTT+conformational+waves+along+the+protofilament+as+a+result+of+local+CTT+perturbations.+The+results+as+presented+support+a+model+in+which+the+cytosolic+electric+fields+and+ionic+currents+generated+by+the+neuronal+excitations+are+%22projected%22+onto+the+CTTs+of+underlying+microtubules+thus+affecting+their+regulatory+function%0D%0Aupon+kinesin+motion+and+MAP+attachment%2Fdetachment.&rft.date=2007&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5813%2F1%2FCTT.pdf&rft.identifier=++Georgiev%2C+Danko+and+Glazebrook%2C+James++(2007)+Conformational+Dynamics+and+Thermal+Cones+of+C-terminal+Tubulin+Tails+in+Neuronal+Microtubules.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5813%2F