?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Solitonic+Effects+of+the+Local+Electromagnetic+Field+on+Neuronal+Microtubules&rft.creator=Georgiev%2C+Danko&rft.creator=Papaioanou%2C+Stelios&rft.creator=Glazebrook%2C+James&rft.subject=Biophysics&rft.subject=Neurophysiology&rft.description=Current+wisdom+in+classical+neuroscience+suggests+that+the+only+direct+action+of+the+electric+field+in+neurons+is+upon+voltage-gated+ion+channels+which+open+and+close+their+gates+during+the+passage+of+ions.+The+intraneuronal+biochemical+activities+are+thought+to+be+modulated+indirectly+either+by+entering+into+the+cytoplasm+ions+that+act+as%0D%0Asecond+messengers%2C+or+via+linkage+to+the+ion+channels+enzymes.+In+this+paper+we+present+a+novel+possibility+for+subneuronal+processing+of+information+by+cytoskeletal+microtubule+tubulin+tails+and+we+show+that+the+local+electromagnetic+field+supports+information+that+could%0D%0Abe+converted+into+specific+protein+tubulin+tail+conformational+states.+Long-range+collective+coherent+behavior+of+the+tubulin+tails+could+be+modelled+in+the+form+of+solitary+waves+such+as+sine-Gordon+kinks%2C+antikinks+or+breathers+that+propagate+along+the+microtubule+outer%0D%0Asurface%2C+and+the+tubulin+tail+soliton+collisions+could+serve+as+elementary+computational+gates+that+control+cytoskeletal+processes.+The+biological+importance+of+the+presented+model+is+due+to+the+unique+biological+enzymatic+energase+action+of+the+tubulin+tails%2C+which+is+experimentally+verified+for+controlling+the+sites+of+microtubule-associated+protein%0D%0Aattachment+and+the+kinesin+transport+of+post-Golgi+vesicles.&rft.date=2007&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F5814%2F1%2Fsolitons_in_brain.pdf&rft.identifier=++Georgiev%2C+Danko+and+Papaioanou%2C+Stelios+and+Glazebrook%2C+James++(2007)+Solitonic+Effects+of+the+Local+Electromagnetic+Field+on+Neuronal+Microtubules.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F5814%2F