---
abstract: 'Renal cell carcinoma is a rare but serious malignancy. Since a reduction in the level of retinoic acid receptor beta 2 (RARbeta2) expression in cancer cells due in part to histone hypoacetylation which is controlled by histone deacetylase (HD), the study on the interaction between cellular retinoic acid-binding proteins II (CRABP II), which is proposed to have its potential influence on retinoic acid (RA) response, and HD can be useful. Comparing to CARBP II and HD, the CARBP II-HD poses the same function and biological process as HD. This can confirm that HD has a significant suppressive effect on the expression of CARBP II. Therefore, reduction in the level of RARbeta2 expression in cancer cells can be expected and this can lead to failure in treatment of renal cell carcinoma with RA. The author hereby purpose that additional HD inhibitor should be added into the regiment of RA to increase the effectiveness of treatment.'
altloc:
  - http://www.ojhas.org/issue25/2008-1-7.htm
chapter: ~
commentary: ~
commref: ~
confdates: ~
conference: ~
confloc: ~
contact_email: ~
creators_id:
  - wviroj@pioneer.netserv.chula.ac.th
creators_name:
  - family: Wiwanitkit
    given: Viroj
    honourific: ''
    lineage: ''
date: 2008-04-10
date_type: published
datestamp: 2008-06-02 00:34:42
department: ~
dir: disk0/00/00/60/88
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edit_lock_user: ~
editors_id:
  - Kakkilaya BS
editors_name:
  - family: Kakkilaya
    given: Srinivas
    honourific: Dr.
    lineage: ''
eprint_status: archive
eprintid: 6088
fileinfo: /style/images/fileicons/application_pdf.png;/6088/1/2008%2D1%2D7.pdf
full_text_status: public
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item_issues_comment: []
item_issues_count: 0
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item_issues_status: []
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keywords: 'Retinoic acid, Cellular retinoic acid-binding proteins, Histone deacetylase, Renal cell carcinoma'
lastmod: 2011-03-11 08:57:08
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: 1
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pubdom: TRUE
publication: Online Journal of Health and Allied Sciences
publisher: Dr. B.S. Kakkilaya
refereed: TRUE
referencetext: "1.\tWeiss RH, Lin PY. Kidney cancer: identification of novel targets for therapy. Kidney Int. 2006;69:224-32.\r\n2.\tGoelden U, Pfoertner S, Hansen W, Toepfer T, von Knobloch R, Hofmann R, Buer J, Schrader AJ. Expression and functional influence of cellular retinoic acid-binding protein II in renal cell carcinoma. Urol Int. 2005;75:269-76.\r\n3.\tTouma SE, Goldberg JS, Moench P, Guo X, Tickoo SK, Gudas LJ, Nanus DM. Retinoic acid and the histone deacetylase inhibitor trichostatin a inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model. Clin Cancer Res. 2005;11:3558-66.\r\n4.\tKhan S, Situ G, Decker K, Schmidt CJ. GoFigure: automated Gene Ontology annotation. Bioinformatics 2003;19:2484-5.\r\n5.\tNagpal S. Retinoids: inducers of tumor/growth suppressors. J Invest Dermatol. 2004;123:xx-xxi.\r\n6.\tSoprano DR, Qin P, Soprano KJ. Retinoic acid receptors and cancers. Annu Rev Nutr. 2004;24:201-21.\r\n7.\tTouma SE, Goldberg JS, Moench P, Guo X, Tickoo SK, Gudas LJ, Nanus DM. Retinoic acid and the histone deacetylase inhibitor trichostatin A inhibit the proliferation of human renal cell carcinoma in a xenograft tumor model. Clin Can Res. 2005;11:3558-3566.\r\n8.\tTrus MR, Yang L, Suarez Saiz F, Bordeleau L, Jurisica I, Minden MD. The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells. Leukemia. 2005;19:1161-8.\r\n9.\tSuenaga M, Soda H, Oka M, Akihiko Yamaguchi A Nakatomi K, Shiozawa K, Kawabata S, Kasai T, Yamada Y, Kamihira S, Tei C, Kohno  S. Histone deacetylase inhibitors suppress telomerase reverse transcriptase mRNA expression in prostate cancer cells. Int J Cancer. 2002;97:621-625"
relation_type: []
relation_uri: []
reportno: ~
rev_number: 19
series: ~
source: ~
status_changed: 2008-06-02 00:34:42
subjects:
  - OJHAS
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: Interaction between cellular retinoic acid-binding protein II and histone hypoacetylation in renal cell carcinoma
type: journale
userid: 4338
volume: 7
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