?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Cyclooxygenase+inhibition+in+ischemic+brain+injury.&rft.creator=Candelario-Jalil%2C+Dr.+Eduardo&rft.creator=Fiebich%2C+Bernd+L.&rft.subject=Neurochemistry&rft.description=Neuroinflammation+is+one+of+the+key+pathological+events+involved+in+the+progression+of+brain+damage+caused+by+cerebral+ischemia.+Metabolism+of+arachidonic+acid+through+cyclooxygenase+(COX)+enzymes+is+known+to+be+actively+involved+in+the+neuroinflammatory+events+leading+to+neuronal+death+after+ischemia.+Two+isoforms+of+COX%2C+termed+COX-1+and+COX-2%2C+have+been+identified.+Unlike+COX-1%2C+COX-2+expression+is+dramatically+induced+by+ischemia+and+appears+to+be+an+effector+of+tissue+damage.+This+review+article+will+focus+specifically+on+the+involvement+of+COX+isozymes+in+brain+ischemia.+We+will+discuss+issues+related+to+the+biochemistry+and+selective+pharmacological+inhibition+of+COX+enzymes%2C+and+further+refer+to+their+expression+in+the+brain+under+normal+conditions+and+following+excitotoxicity+and+ischemic+cerebral+injury.+We+will+review+present+knowledge+of+the+relative+contribution+of+each+COX+isoform+to+the+brain+ischemic+pathology%2C+based+on+data+from+investigations+utilizing+selective+COX-1%2FCOX-2+inhibitors+and+genetic+knockout+mouse+models.+The+mechanisms+of+neurotoxicity+associated+with+increased+COX+activity+after+ischemia+will+also+be+examined.+Finally%2C+we+will+provide+a+critical+evaluation+of+the+therapeutic+potential+of+COX+inhibitors+in+cerebral+ischemia+and+discuss+new+targets+downstream+of+COX+with+potential+neuroprotective+ability.&rft.publisher=Bentham+Science+Publishers&rft.date=2008&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6132%2F1%2FCurr_Pharm_Des_2008_Candelario-Jalil_and_Fiebich.pdf&rft.identifier=++Candelario-Jalil%2C+Dr.+Eduardo+and+Fiebich%2C+Bernd+L.++(2008)+Cyclooxygenase+inhibition+in+ischemic+brain+injury.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6132%2F