?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Amniotic+Fluid+Ingestion+Before+Vaginal%2FCervical+Stimulation+Produces+a+Dose-Dependent+Enhancement+of+Analgesia+and+Blocks+Pseudopregnancy&rft.creator=Thompson%2C+Alexis+C.&rft.creator=Abbott%2C+Patricia&rft.creator=Doerr%2C+Jean+C.&rft.creator=Ferguson%2C+Elizabeth+J.+&rft.creator=Kristal%2C+Dr.+Mark+B.&rft.subject=Neuroendocrinology&rft.subject=Psychobiology&rft.subject=Comparative+Psychology&rft.description=A+substance+in+amniotic+fluid+(AF)+and+placenta+has+been+shown+to+enhance+analgesia+produced+by+morphine%2C+late+pregnancy%2C+footshock%2C+and+vaginal%2Fcervical+stimulation+(VS).+When+morphine-induced+analgesia+was+assessed+previously%2C+the+degree+of+enhancement+by+ingestion+of+AF+or+placenta+was+found+to+be+a+function+of+the+amount+of+analgesia+being+generated.+We+have+extended+these+results+to+include+the+analgesia+produced+by+VS.+Analgesia+induced+by+75%2C+125%2C+175%2C+or+225+g+of+vaginal%2Fcervical+pressure+was+measured+in+rats+pretreated+with+0.25+ml+(by+orogastric+infusion)+of+either+AF+or+saline.+AF+infusion+enhanced+the+analgesia+produced+by+125+g+VS%2C+but+did+not+affect+the+analgesia+produced+by+75%2C+175%2C+or+225+g+VS.+Unexpectedly%2C+we+also+found+that+infusion+of+AF+shortly+before+the+application+of+VS+prevents+VS-induced+pseudopregnancy+(PsP).+Whereas+the+incidence+of+PsP+following+75%2C+125%2C+or+175+g+VS+was+less+than+19%25+and+not+statistically+different+for+AF+and+saline+pretreatments%2C+the+incidence+of+PsP+after+225+g+VS+was+44%25+in+saline-pretreated+rats%2C+but+only+10%25+in+AF-pretreated+rats.+Protection+from+the+induction+of+pseudopregnancy%2C+which+could+be+caused+by+mechanical+stimulation+of+the+cervical+area+during+delivery%2C+may+be+an+additional+benefit+of+parturitional+ingestion+of+placenta+and+amniotic+fluid+(placentophagia).&rft.publisher=Pergamon+Press&rft.date=1991&rft.type=Journal+(Paginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6189%2F1%2FPseudopreg.pdf&rft.identifier=++Thompson%2C+Alexis+C.+and+Abbott%2C+Patricia+and+Doerr%2C+Jean+C.+and+Ferguson%2C+Elizabeth+J.++and+Kristal%2C+Dr.+Mark+B.++(1991)+Amniotic+Fluid+Ingestion+Before+Vaginal%2FCervical+Stimulation+Produces+a+Dose-Dependent+Enhancement+of+Analgesia+and+Blocks+Pseudopregnancy.++%5BJournal+(Paginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6189%2F