?url_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rft.title=Hypoxia+Inducible+Factor-1%CE%B1+(HIF-1+%CE%B1)+and+its+Role+in+Tumour+Progression+to+Malignancy&rft.creator=Sharma%2C+Gaurav+Mrinal&rft.subject=Online+Journal+of+Health+and+Allied+Sciences&rft.description=Hypoxia+is+a+condition+in+which+an+area+of+the+body+or+a+tissue+is+deprived+of+sufficient+supply+of+oxygen.+The+lack+of+nutrients+in+a+hypoxic+tissue+generally+causes+apoptosis+but+some+cells+are+able+to+adapt+to+this+hypoxic+environment+and+resist+apoptosis.+This+adaptation+occurs+as+a+result+of+gene+activation.+Hypoxia+is+a+characteristic+feature+of+many+cancers+and+is+the+stimulus+for+overexpression+of+HIF-1%CE%B1+-+a+basic+loop-helix+PAS+protein+family+subunit+of+HIF%2C+which+allows+the+cell+to+adapt+and+survive+in+hostile+environment.+The+presence+of+hypoxia+and+HIF-1%CE%B1+is+correlated+with+an+increased+risk+of+metastasis+and+techniques+that+can+inhibit+hypoxia+inducible+factor+may+be+instrumental+in+finding+a+cure+for+cancer&rft.publisher=Dr.+B.S.+Kakkilaya&rft.contributor=Kakkilaya%2C+Dr.+Srinivas&rft.date=2008-07-21&rft.type=Journal+(On-line%2FUnpaginated)&rft.type=PeerReviewed&rft.format=application%2Fpdf&rft.identifier=http%3A%2F%2Fcogprints.org%2F6202%2F1%2F2008-2-6.pdf&rft.identifier=++Sharma%2C+Gaurav+Mrinal++(2008)+Hypoxia+Inducible+Factor-1%CE%B1+(HIF-1+%CE%B1)+and+its+Role+in+Tumour+Progression+to+Malignancy.++%5BJournal+(On-line%2FUnpaginated)%5D+++++&rft.relation=http%3A%2F%2Fcogprints.org%2F6202%2F