TY  - GEN
ID  - cogprints6202
UR  - http://cogprints.org/6202/
A1  - Sharma, Gaurav Mrinal
Y1  - 2008/07/21/
N2  - Hypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able to adapt to this hypoxic environment and resist apoptosis. This adaptation occurs as a result of gene activation. Hypoxia is a characteristic feature of many cancers and is the stimulus for overexpression of HIF-1? - a basic loop-helix PAS protein family subunit of HIF, which allows the cell to adapt and survive in hostile environment. The presence of hypoxia and HIF-1? is correlated with an increased risk of metastasis and techniques that can inhibit hypoxia inducible factor may be instrumental in finding a cure for cancer
PB  - Dr. B.S. Kakkilaya
KW  - HIF
KW  -  HIF-1?
KW  -  Hypoxia
KW  -  Malignancy
KW  -  Cancer
KW  -  Cancer Therapy
TI  - Hypoxia Inducible Factor-1? (HIF-1 ?) and its Role in Tumour Progression to Malignancy
AV  - public
ER  -

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