%A Gaurav Mrinal Sharma
%J Online Journal of Health and Allied Sciences
%T Hypoxia Inducible Factor-1? (HIF-1 ?) and its Role in Tumour Progression to Malignancy
%X Hypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able to adapt to this hypoxic environment and resist apoptosis. This adaptation occurs as a result of gene activation. Hypoxia is a characteristic feature of many cancers and is the stimulus for overexpression of HIF-1? - a basic loop-helix PAS protein family subunit of HIF, which allows the cell to adapt and survive in hostile environment. The presence of hypoxia and HIF-1? is correlated with an increased risk of metastasis and techniques that can inhibit hypoxia inducible factor may be instrumental in finding a cure for cancer
%N 2
%K HIF, HIF-1?, Hypoxia, Malignancy, Cancer, Cancer Therapy
%E Dr. Srinivas Kakkilaya
%V 7
%D 2008
%I Dr. B.S. Kakkilaya
%L cogprints6202

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