creators_name: Sharma, Gaurav Mrinal
creators_id: gauravmrinal@gmail.com
editors_name: Kakkilaya, Srinivas
editors_id: Kakkilaya BS
type: journale
datestamp: 2008-09-19 13:59:25
lastmod: 2011-03-11 08:57:11
metadata_visibility: show
title: Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy
ispublished: pub
subjects: OJHAS
full_text_status: public
keywords: HIF, HIF-1α, Hypoxia, Malignancy, Cancer, Cancer Therapy
abstract: Hypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able to adapt to this hypoxic environment and resist apoptosis. This adaptation occurs as a result of gene activation. Hypoxia is a characteristic feature of many cancers and is the stimulus for overexpression of HIF-1α - a basic loop-helix PAS protein family subunit of HIF, which allows the cell to adapt and survive in hostile environment. The presence of hypoxia and HIF-1α is correlated with an increased risk of metastasis and techniques that can inhibit hypoxia inducible factor may be instrumental in finding a cure for cancer
date: 2008-07-21
date_type: published
publication: Online Journal of Health and Allied Sciences
volume: 7
number: 2
publisher: Dr. B.S. Kakkilaya
refereed: TRUE
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citation:   Sharma, Gaurav Mrinal  (2008) Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy.  [Journal (On-line/Unpaginated)]     
document_url: http://cogprints.org/6202/1/2008-2-6.pdf