---
abstract: 'Hypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able to adapt to this hypoxic environment and resist apoptosis. This adaptation occurs as a result of gene activation. Hypoxia is a characteristic feature of many cancers and is the stimulus for overexpression of HIF-1α - a basic loop-helix PAS protein family subunit of HIF, which allows the cell to adapt and survive in hostile environment. The presence of hypoxia and HIF-1α is correlated with an increased risk of metastasis and techniques that can inhibit hypoxia inducible factor may be instrumental in finding a cure for cancer'
altloc:
  - http://www.ojhas.org/issue26/2008-2-6.htm
chapter: ~
commentary: ~
commref: ~
confdates: ~
conference: ~
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contact_email: ~
creators_id:
  - gauravmrinal@gmail.com
creators_name:
  - family: Sharma
    given: Gaurav Mrinal
    honourific: ''
    lineage: ''
date: 2008-07-21
date_type: published
datestamp: 2008-09-19 13:59:25
department: ~
dir: disk0/00/00/62/02
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editors_id:
  - Kakkilaya BS
editors_name:
  - family: Kakkilaya
    given: Srinivas
    honourific: Dr.
    lineage: ''
eprint_status: archive
eprintid: 6202
fileinfo: /style/images/fileicons/application_pdf.png;/6202/1/2008%2D2%2D6.pdf
full_text_status: public
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isbn: ~
ispublished: pub
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item_issues_comment: []
item_issues_count: 0
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item_issues_reported_by: []
item_issues_resolved_by: []
item_issues_status: []
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keywords: 'HIF, HIF-1α, Hypoxia, Malignancy, Cancer, Cancer Therapy'
lastmod: 2011-03-11 08:57:11
latitude: ~
longitude: ~
metadata_visibility: show
note: ~
number: 2
pagerange: ~
pubdom: TRUE
publication: Online Journal of Health and Allied Sciences
publisher: Dr. B.S. Kakkilaya
refereed: TRUE
referencetext: "1.\tRockwell, S., Yuan, J., Peretz, S., & Glazer, P. M. (2001). Geneomic instability in cancer. Novartis Foundation Symposium. 240, 133-42.\r\n2.\tGreijer A E and van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. Journal of Clinical Pathology. October 2004;57(10):1009-1014\r\n3.\tSemenza, G., Shimoda, L. A., & Prabhakar, N. (2005). Regulation of gene expression by HIF-1. Novartis Foundation Symposium. 272, 2-14.\r\n4.\tMyles R. Joyce, Aoife M. Shannon, Judith Harmey, James Geraghtyb and David Bouchier-Hayes. Oncological implications of hypoxia inducible factor-1α (HIF-1α) expression. Cancer Treatment Reviews. October 2006;32(6):407-416 \r\n5.\tPhua, H. H. (2003). Developing tools for screening therapeutic compounds against the hypoxia-inducible transcription factor-1 (HIF-1) pathway. Unpublished master's thesis. University of Auckland, Auckland, New Zealand.\r\n6.\tBrahimi-Horn, C., Berra, E., & Pouyssegur, J. (). Hypoxia: the tumor's gateway to progression along the angiogenic pathway. Trends in Cell Biology 2001;11(11):S32-S36.\r\n7.\tRandy L. Jensen, Brian T. Ragel, Kum Whang and David Gillespie. Inhibition of hypoxia inducible factor-1a (HIF-1a) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas. Journal of Neuro-Oncology. 2006;78:233–247\r\n8.\tKang Min, Kim Hyon, Kim Hyung, Lee Ji, Kim Dae, Jung, Kyung et al. The effect of age and calorie restriction on HIF-1-responsive genes in aged liver. Biogerontology. January 2005;6(1):27-3\r\n9.\tHua Zhong, Angelo M. De Marzo, Erik Laughner, Michael Lim, David A. Hilton, David Zagzag et al. Overexpression of Hypoxia-inducible Factor 1a in Common Human Cancers and Their Metastases. Cancer Research. November 1999;59:5830-5835.\r\n10.\tKevin J. Turner, John W. Moore, Adam Jones, Claire F. Taylor, Darren Cuthbert-Heavens, Cheng Han et al. Expression of Hypoxia-inducible Factors in Human Renal Cancer: Relationship to Angiogenesis and to the von Hippel-Lindau Gene Mutation. Cancer Research. May 15, 2002;62:2957–2961\r\n11.\tMabjeesh NJ, Amir S. Hypoxia-inducible factor (HIF) in human tumorigenesis. Histology and Histopathology. 2007;22:559-572\r\n12.\tGregg L Semenza. Development of novel therapeutic strategies that target HIF-1. Expert Opinion on Therapeutic Targets. April 2006;10(2):267-280"
relation_type: []
relation_uri: []
reportno: ~
rev_number: 19
series: ~
source: ~
status_changed: 2008-09-19 13:59:25
subjects:
  - OJHAS
succeeds: ~
suggestions: ~
sword_depositor: ~
sword_slug: ~
thesistype: ~
title: Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy
type: journale
userid: 4338
volume: 7
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