2008-09-19T13:55:05Z2011-03-11T08:57:12Zhttp://cogprints.org/id/eprint/6211This item is in the repository with the URL: http://cogprints.org/id/eprint/62112008-09-19T13:55:05ZAmniotic-Fluid Ingestion Enhances the Central
Analgesic Effect of MorphineAmniotic fluid and placenta contain a substance (POEF) that when ingested enhances opioid-mediated analgesia produced by several agents (morphine injection, vaginal/cervical stimulation, late pregnancy, footshock), but not that produced by aspirin injection. The present series of experiments employed quaternary naltrexone, an opioid antagonist that does not readily cross the blood-brain barrier, in conjunction with either peripheral or central administration of morphine, to determine whether amniotic-fluid ingestion (and therefore POEF ingestion) enhances opioid-mediated analgesia by affecting the central and/or peripheral actions of morphine. The results suggest that POEF affects only the central analgesic effects of morphine.Jean M. DiPirrodipirrjm@buffalostate.eduAlexis C. Thompsonathompso@ria.buffalo.eduDr. Mark B. Kristalkristal@buffalo.edu